PMID- 25051493
OWN - NLM
STAT- MEDLINE
DCOM- 20160208
LR  - 20150324
IS  - 1532-4281 (Electronic)
IS  - 1079-9893 (Linking)
VI  - 35
IP  - 1
DP  - 2015 Feb
TI  - Association of monocyte chemoattractant protein-1 2518G/A gene polymorphism with 
      diabetic nephropathy risk.
PG  - 94-7
LID - 10.3109/10799893.2014.936458 [doi]
AB  - Results from the published studies on the association between monocyte 
      chemoattractant protein-1 (MCP-1) -2518 A/G gene polymorphism and diabetic 
      nephropathy (DN) risk are still conflicting. This meta-analysis was performed to 
      evaluate the relationship between MCP-1 A/G gene polymorphism and DN risk and to 
      explore whether MCP-1 A allele, AA genotype or GG genotype could become a 
      predictive marker for DN risk. Association studies were identified from the 
      databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological 
      Medicine Database) as of 1 March 2014, and eligible investigations were 
      synthesized using meta-analysis method. Four studies were identified for the 
      analysis of association between MCP-1 A/G gene polymorphism and DN risk, and all 
      the included studies were form Asian population. The association between MCP-1 
      A/G gene polymorphism and DN susceptibility was not found (A allele: OR = 1.19; 
      95% CI: 0.97-1.45; p = 0.10; AA genotype: OR = 1.27; 95% CI: 0.95-1.70; p = 0.11; 
      GG genotype: OR = 0.77; 95% CI: 0.57-1.05; p = 0.10). In the sensitive analysis, 
      according to the control source from hospital, we found that AA genotype was 
      associated with the DN risk (OR = 1.45; 95% CI: 1.05-2.00; p = 0.02). However, 
      other associations were not found in the sensitive analysis according to the 
      control source from hospital or population. Our results indicate that AA 
      homozygous might be a significant genetic molecular marker to predict the 
      diabetes mellitus patients developing into DN. However, more investigations are 
      required to further clarify this association.
FAU - Su, Ning
AU  - Su N
AD  - Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University , 
      Guangzhou , China and.
FAU - Li, Hong-Yan
AU  - Li HY
FAU - Huang, Miao-Fang
AU  - Huang MF
FAU - Jiang, Zong-Pei
AU  - Jiang ZP
FAU - Zhou, Tian-Biao
AU  - Zhou TB
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20140722
PL  - England
TA  - J Recept Signal Transduct Res
JT  - Journal of receptor and signal transduction research
JID - 9509432
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Alleles
MH  - Chemokine CCL2/*genetics
MH  - China
MH  - Diabetes Mellitus, Type 2/*genetics/pathology
MH  - Diabetic Nephropathies/*genetics/pathology
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
OTO - NOTNLM
OT  - A/G gene polymorphism
OT  - diabetes mellitus
OT  - diabetic nephropathy
OT  - meta-analysis
OT  - monocyte chemoattractant protein-1
EDAT- 2014/07/23 06:00
MHDA- 2016/02/09 06:00
CRDT- 2014/07/23 06:00
PHST- 2014/07/23 06:00 [entrez]
PHST- 2014/07/23 06:00 [pubmed]
PHST- 2016/02/09 06:00 [medline]
AID - 10.3109/10799893.2014.936458 [doi]
PST - ppublish
SO  - J Recept Signal Transduct Res. 2015 Feb;35(1):94-7. doi: 
      10.3109/10799893.2014.936458. Epub 2014 Jul 22.