PMID- 25052186
OWN - NLM
STAT- MEDLINE
DCOM- 20151124
LR  - 20211021
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 41
IP  - 10
DP  - 2014 Oct
TI  - Combined effects of the BDNF rs6265 (Val66Met) polymorphism and environment risk 
      factors on psoriasis vulgaris.
PG  - 7015-22
LID - 10.1007/s11033-014-3589-4 [doi]
AB  - Smoking, alcohol consumption and higher body mass index (BMI) are well 
      established risk factors for psoriasis and also associated with the clinical 
      traits of the disease. And the genetic influences on these three risk factors 
      indeed exist. Previously studies have demonstrated these risk factors related 
      genetic variants may also play a role in the development of risk factors-related 
      diseases. Then we performed a hospital-based study in order to evaluate the 
      combined effect of the risk factors and their related polymorphism rs6265 in 
      brain-derived neurotrophic factor (BDNF) gene on psoriasis vulgaris (PV) risk and 
      clinic traits. The case-control study involved 660 subjects including 345 cases 
      and 315 controls in Chinese Han population. The variant of rs6265 was typed by 
      SNaPshot Multiplex Kit (Applied Biosystems Co., USA). We confirmed that higher 
      BMI (>/=25), smoking and alcohol consumption were risk factors for PV, and the 
      estimated ORs were 1.63(95 % confidence interval (CI); 1.12-2.37), 2.09(95 % CI; 
      1.44-3.03) and 1.65(95 % CI; 1.15-2.37) respectively. Genotype and allele 
      distributions did not differ significantly between case and control. However, we 
      found combined effect of rs6265 genotype (GG) and higher BMI (>/=25) increased risk 
      of PV (OR = 2.09; 95 % CI, 1.02-4.28; P < 0.05; adjusted OR = 3.19; 95 % CI, 
      1.37-7.45; P < 0.05) and clinically severity of PV (OR = 2.71; 95 % CI, 
      1.09-6.72; P < 0.05; adjusted OR = 1.25; 95 % CI, 1.10-1.40; P < 0.05). But none 
      such significant combined effect was observed between others genotype (AA and AG) 
      and other risk factors. In conclusions, the combined effect of BDNF rs6265 
      genotype (GG) and higher BMI may increases the risk and clinical severity of PV 
      in Chinese Han population.
FAU - Quan, Cheng
AU  - Quan C
AD  - Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai, China.
FAU - Zhu, Kun-Ju
AU  - Zhu KJ
FAU - Zhang, Chi
AU  - Zhang C
FAU - Liu, Zhong
AU  - Liu Z
FAU - Liu, Huan
AU  - Liu H
FAU - Zhu, Cheng-Yao
AU  - Zhu CY
FAU - Li, Ke-Shen
AU  - Li KS
FAU - Fan, Yi-Ming
AU  - Fan YM
FAU - Zheng, Jie
AU  - Zheng J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140723
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - *Environment
MH  - Female
MH  - Gene-Environment Interaction
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
MH  - Psoriasis/diagnosis/*etiology
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2014/07/24 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/07/24 06:00
PHST- 2013/10/15 00:00 [received]
PHST- 2014/07/05 00:00 [accepted]
PHST- 2014/07/24 06:00 [entrez]
PHST- 2014/07/24 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1007/s11033-014-3589-4 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2014 Oct;41(10):7015-22. doi: 10.1007/s11033-014-3589-4. Epub 2014 
      Jul 23.