PMID- 25052557
OWN - NLM
STAT- MEDLINE
DCOM- 20141124
LR  - 20211021
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 34
IP  - 10
DP  - 2014 Oct
TI  - Brain BDNF levels elevation induced by physical training is reduced after 
      unilateral common carotid artery occlusion in rats.
PG  - 1681-7
LID - 10.1038/jcbfm.2014.133 [doi]
AB  - We investigated the contribution of blood flow elevation in the 
      cerebrovasculature to physical training-induced brain-derived neurotrophic factor 
      (BDNF) levels elevation in the brain. Brain-derived neurotrophic factor protein 
      levels were measured in the motor cortex 24 h after the last session of a forced 
      treadmill walking (30 minutes a day, 18 m/minute for 7 consecutive days). 
      Unilateral common carotid artery occlusion and modulation of exercise intensity 
      (0 versus -10% inclination of the treadmill) were used as strategies to reduce 
      the (normal) elevation of flow in the cerebrovasculature occurring during 
      exercise. Administration of N-nitro-L-arginine methyl ester (L-NAME, 60 mg/kg 
      before each exercise sessions) and genetic hypertension (spontaneously 
      hypertensive rats) were used as approaches to reduce stimulation of nitric oxide 
      production in response to shear stress elevation. Vascular occlusion totally and 
      partially abolished the effect of physical training on BDNF levels in the 
      hemisphere ipsilateral and contralateral to occlusion, respectively. BDNF levels 
      were higher after high than low exercise intensity. In addition, both genetic 
      hypertension and L-NAME treatment blunted the effects of physical training on 
      BDNF. From these results, we propose that elevation of brain BDNF levels elicited 
      by physical training involves changes in cerebral hemodynamics.
FAU - Banoujaafar, Hayat
AU  - Banoujaafar H
AD  - Unite INSERM U1093 Cognition, Action et Plasticite Sensorimotrice, Universite de 
      Bourgogne, Dijon, France.
FAU - Van Hoecke, Jacques
AU  - Van Hoecke J
AD  - Unite INSERM U1093 Cognition, Action et Plasticite Sensorimotrice, Universite de 
      Bourgogne, Dijon, France.
FAU - Mossiat, Claude M
AU  - Mossiat CM
AD  - Unite INSERM U1093 Cognition, Action et Plasticite Sensorimotrice, Universite de 
      Bourgogne, Dijon, France.
FAU - Marie, Christine
AU  - Marie C
AD  - Unite INSERM U1093 Cognition, Action et Plasticite Sensorimotrice, Universite de 
      Bourgogne, Dijon, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140723
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Enzyme Inhibitors)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Animals
MH  - Arterial Occlusive Diseases/*metabolism/physiopathology
MH  - Brain/*blood supply/drug effects/*metabolism/physiopathology
MH  - Brain-Derived Neurotrophic Factor/analysis/*metabolism
MH  - Carotid Artery, Common/*metabolism/physiopathology
MH  - Enzyme Inhibitors/pharmacology
MH  - Hemodynamics
MH  - Hypertension/genetics/metabolism
MH  - Male
MH  - NG-Nitroarginine Methyl Ester/pharmacology
MH  - Nitric Oxide/metabolism
MH  - Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Wistar
PMC - PMC4269729
EDAT- 2014/07/24 06:00
MHDA- 2014/12/15 06:00
PMCR- 2015/10/01
CRDT- 2014/07/24 06:00
PHST- 2014/04/18 00:00 [received]
PHST- 2014/06/17 00:00 [revised]
PHST- 2014/06/26 00:00 [accepted]
PHST- 2014/07/24 06:00 [entrez]
PHST- 2014/07/24 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - jcbfm2014133 [pii]
AID - 10.1038/jcbfm.2014.133 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2014 Oct;34(10):1681-7. doi: 10.1038/jcbfm.2014.133. 
      Epub 2014 Jul 23.