PMID- 25052558
OWN - NLM
STAT- MEDLINE
DCOM- 20141124
LR  - 20211021
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 34
IP  - 10
DP  - 2014 Oct
TI  - Juvenile traumatic brain injury induces long-term perivascular matrix changes 
      alongside amyloid-beta accumulation.
PG  - 1637-45
LID - 10.1038/jcbfm.2014.124 [doi]
AB  - In our juvenile traumatic brain injury (jTBI) model, emergence of cognitive 
      dysfunctions was observed up to 6 months after trauma. Here we hypothesize that 
      early brain injury induces changes in the neurovascular unit (NVU) that would be 
      associated with amyloid-beta (Abeta) accumulation. We investigated NVU changes for 
      up to 6 months in a rat jTBI model, with a focus on the efflux protein 
      P-glycoprotein (P-gp) and on the basement membrane proteins perlecan and 
      fibronectin, all known to be involved in Abeta clearance. Rodent-Abeta staining is 
      present and increased after jTBI around cerebral blood microvessels, and the 
      diameter of those is decreased by 25% and 34% at 2 and 6 months, respectively, 
      without significant angiogenesis. P-glycoprotein staining in endothelium is 
      decreased by 22% and parallels an increase of perlecan and fibronectin staining 
      around cerebral blood vessels. Altogether, these results strongly suggest that 
      the emergence of long-term behavioral dysfunctions observed in rodent jTBI may be 
      related to endothelial remodeling at the blood-brain barrier alongside vascular 
      dysfunction and altered Abeta trafficking. This study shows that it is important to 
      consider jTBI as a vascular disorder with long-term consequences on cognitive 
      functions.
FAU - Jullienne, Amandine
AU  - Jullienne A
AD  - Department of Pediatrics, Loma Linda University, Loma Linda, California, USA.
FAU - Roberts, Jill M
AU  - Roberts JM
AD  - Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
FAU - Pop, Viorela
AU  - Pop V
AD  - Department of Pediatrics, Loma Linda University, Loma Linda, California, USA.
FAU - Paul Murphy, M
AU  - Paul Murphy M
AD  - Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
FAU - Head, Elizabeth
AU  - Head E
AD  - Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
FAU - Bix, Gregory J
AU  - Bix GJ
AD  - Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
FAU - Badaut, Jerome
AU  - Badaut J
AD  - 1] Department of Pediatrics, Loma Linda University, Loma Linda, California, USA 
      [2] Department of Physiology, Loma Linda University, Loma Linda, California, USA 
      [3] CNRS UMR 5287, Bordeaux University, Bordeaux, France.
LA  - eng
GR  - R01 HD061946/HD/NICHD NIH HHS/United States
GR  - R01 NS065842/NS/NINDS NIH HHS/United States
GR  - R01HD061946/HD/NICHD NIH HHS/United States
GR  - R01NS065842/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140723
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Fibronectins)
RN  - 0 (Heparan Sulfate Proteoglycans)
RN  - 143972-95-6 (perlecan)
SB  - IM
MH  - Amyloid beta-Peptides/*metabolism
MH  - Animals
MH  - Blood-Brain Barrier/metabolism/pathology
MH  - Brain/*blood supply/metabolism/*pathology
MH  - Brain Injuries/metabolism/*pathology
MH  - Fibronectins/analysis/metabolism
MH  - Heparan Sulfate Proteoglycans/analysis/metabolism
MH  - Male
MH  - Microcirculation
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC4269722
EDAT- 2014/07/24 06:00
MHDA- 2014/12/15 06:00
PMCR- 2015/10/01
CRDT- 2014/07/24 06:00
PHST- 2014/02/16 00:00 [received]
PHST- 2014/04/28 00:00 [revised]
PHST- 2014/06/05 00:00 [accepted]
PHST- 2014/07/24 06:00 [entrez]
PHST- 2014/07/24 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - jcbfm2014124 [pii]
AID - 10.1038/jcbfm.2014.124 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2014 Oct;34(10):1637-45. doi: 10.1038/jcbfm.2014.124. 
      Epub 2014 Jul 23.