PMID- 25053366
OWN - NLM
STAT- MEDLINE
DCOM- 20150422
LR  - 20211021
IS  - 1873-4251 (Electronic)
IS  - 1570-162X (Print)
IS  - 1570-162X (Linking)
VI  - 12
IP  - 4
DP  - 2014
TI  - Brain derived neurotrophic factor and cognitive status: the delicate balance 
      among people living with HIV, with and without alcohol abuse.
PG  - 254-64
AB  - INTRODUCTION: The advent of combination antiretroviral therapy(cART) has lead to 
      a significant reduction in morbidity and mortality among people living with 
      HIV(PLWH). However, HIV-associated neurocognitive disorders (HAND) still remain a 
      significant problem. One possible mechanism for the persistence of these 
      disorders is through the effect of HIV on brain-derived neurotrophic factor 
      (BDNF). BDNF is influenced by various factors including hazardous alcohol use 
      (HAU), which is prevalent among PLWH. This study attempts to elucidate the 
      relationships between HAU, BDNF and HAND. METHODS: Cross-sectional analyses were 
      conducted on a sample of 199 hazardous alcohol users and 198 non-HAU living with 
      HIV. Members of each group were matched according to sociodemographic 
      characteristics and CD4 count. Research procedures included validated 
      questionnaires, neuropsychological assessments and a blood sample to obtain BDNF 
      and immune measurements. RESULTS: Hazardous alcohol users showed either 
      significantly lower or significantly higher BDNF levels compared to the 
      Non-hazardous (OR=1,4; 95% CI: 1-2.1, p = 0.003). Therefore, for additional 
      analyses, subjects were categorized based on BDNF values in: Group 1 < 4000, 
      Group 2: 4001-7,999 (reference group), and Group 3 for those >8,000 pg/mL. Groups 
      1 and 3 performed significantly worse than those in Group 2 in the domains of 
      processing speed, auditory-verbal and visuospatial learning and memory. 
      Multivariate analyses confirmed that HAU and BDNF are significant contributors of 
      HAND. CONCLUSION: Our findings offer novel insights into the relationships 
      between BDNF, and alcohol use among PLWH. Our results also lend support to 
      expanding clinical movement to use BDNF as an intervention target for PLWH, in 
      those with evidence of deficiencies, and highlight the importance of including 
      HAUat the inception of clinical trials.
FAU - Miguez-Burbano, Maria Jose
AU  - Miguez-Burbano MJ
FAU - Espinoza, Luis
AU  - Espinoza L
FAU - Whitehead, Nicole Ennis
AU  - Whitehead NE
FAU - Bryant, Vaughn E
AU  - Bryant VE
FAU - Vargas, Mayra
AU  - Vargas M
FAU - Cook, Robert L
AU  - Cook RL
FAU - Quiros, Clery
AU  - Quiros C
FAU - Lewis, John E
AU  - Lewis JE
FAU - Deshratan, Asthana
AU  - Deshratan A
AD  - School of Integrated Science and Humanity, Florida International University, 
      Miami, FL, USA. mjmiguez@fiu.edu.
LA  - eng
GR  - R01 AA018095/AA/NIAAA NIH HHS/United States
GR  - U24 AA022002/AA/NIAAA NIH HHS/United States
GR  - 1U24AA022002-01/AA/NIAAA NIH HHS/United States
GR  - R01 AA018095-01A1/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - Netherlands
TA  - Curr HIV Res
JT  - Current HIV research
JID - 101156990
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - AIDS Dementia Complex/*etiology
MH  - Acquired Immunodeficiency Syndrome/*complications/*immunology
MH  - Adult
MH  - Alcoholism/*complications
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
PMC - PMC4508013
MID - NIHMS706223
COIS- CONFLICT OF INTEREST The author(s) report(s) no real or perceived vested 
      interests that relate to this article that could be construed as a conflict of 
      interest. However, we would like to report that Dr. Espinoza has the following 
      pharmaceutical relationship: Research support: Gilead, Abbott. He is also a 
      consultant for: ViiV, Gilead.
EDAT- 2014/07/24 06:00
MHDA- 2015/04/23 06:00
PMCR- 2015/07/20
CRDT- 2014/07/24 06:00
PHST- 2014/04/06 00:00 [received]
PHST- 2014/04/07 00:00 [revised]
PHST- 2014/04/07 00:00 [accepted]
PHST- 2014/07/24 06:00 [entrez]
PHST- 2014/07/24 06:00 [pubmed]
PHST- 2015/04/23 06:00 [medline]
PHST- 2015/07/20 00:00 [pmc-release]
AID - CHRE-EPUB-61487 [pii]
AID - 10.2174/1570162x12666140721121238 [doi]
PST - ppublish
SO  - Curr HIV Res. 2014;12(4):254-64. doi: 10.2174/1570162x12666140721121238.