PMID- 25053932
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140723
LR  - 20211021
IS  - 1660-3796 (Print)
IS  - 1660-3818 (Electronic)
IS  - 1660-3796 (Linking)
VI  - 41
IP  - 3
DP  - 2014 Jun
TI  - Hemostatic function and transfusion efficacy of apheresis platelet concentrates 
      treated with gamma irradiation in use for thrombocytopenic patients.
PG  - 189-96
LID - 10.1159/000363523 [doi]
AB  - BACKGROUND: During the transfusion of blood components, the transfer of 
      allogeneic donor white blood cells (WBCs) can mediate transfusion-associated 
      graft-versus-host disease (TA-GVHD). To minimize the reaction, exposure of blood 
      products to gamma irradiation is currently the standard of care. The aim of our 
      study was to evaluate and compare hemostatic function, transfusion efficacy, and 
      safety of gamma-irradiated single-donor apheresis platelet concentrates (PCs) and 
      of conventional non-irradiated PCs in patients with chemotherapy-induced 
      thrombocytopenia. METHODS: 20 double-dose single-donor leukoreduced PCs were 
      split in two identical units; one was gamma-irradiated with 25 Gy (study arm A) 
      and the other remains non-irradiated (study arm B). Both units were stored under 
      equal conditions. Hematologic patients were randomly assigned to receive 
      gamma-irradiated or conventional non-irradiated PCs. Hemostatic function was 
      evaluated by thrombelastography (TEG). TEG measurements were taken pre 
      transfusion and 1 and 24 h post transfusion. TEG profiles were measured, noting 
      the time to initiate clotting (R), the angle of clot formation (alpha), and the 
      maximum amplitude (clot strength (MA)). Whole blood samples were collected from 
      these thrombocytopenic patients at 1 and 24 h for PLT count increments (CIs) and 
      corrected count increments (CCIs) with assessments of transfusion efficacy. Time 
      to next PLT transfusion, transfusion requirement of RBCs, active bleeding, and 
      adverse events (AEs), were analyzed. RESULTS: No differences could be found in 
      hemostatic function parameters (MA, R, and alpha) between study arms A and B (all p 
      values > 0.096) pre transfusion as well as 1 and 24 h post transfusion. No 
      differences between study arms A and B were observed for mean (+/- standard 
      deviation (SD)) 1-hour CCI (12.83 +/- 6.33 vs. 11.59 +/- 5.97) and 24-hour CCI (6.56 
      +/- 4.10 vs. 5.76 +/- 4.05). Mean 1-hour CI and 24-hour CI were not significantly 
      different in both study arms (p = 0.254 and p = 0.242 respectively). Median time 
      to the next PC transfusion after study PC was not significantly different between 
      groups: (2.4 vs. 2.2 days, p = 0.767). No differences could be found in 
      transfusion requirement of red blood cells (p = 0.744) between both study arms. 
      There were also no regarding bleeding, adverse events, and acute transfusion 
      reaction(s). CONCLUSIONS: This study confirms safety of gamma-irradiated PCs for 
      treatment thrombocytopenia. Hemostatic function, transfusion efficacy, bleeding, 
      and safety of single-donor apheresis PCs treated with gamma irradiation versus 
      untreated control PCs are comparable.
FAU - Zhu, Mei
AU  - Zhu M
AD  - Department of Nuclear Medicine, The Third Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui, China.
FAU - Xu, Wei
AU  - Xu W
AD  - Department of Blood Transfusion, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui, China.
FAU - Wang, Bao-Long
AU  - Wang BL
AD  - Department of Nuclear Medicine, The Third Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui, China.
FAU - Su, Hong
AU  - Su H
AD  - Department of Epidemiology & Biostatistics, School of Public Health, Anhui 
      Medical University, Hefei, Anhui, China.
LA  - eng
PT  - Journal Article
DEP - 20140522
PL  - Switzerland
TA  - Transfus Med Hemother
JT  - Transfusion medicine and hemotherapy : offizielles Organ der Deutschen 
      Gesellschaft fur Transfusionsmedizin und Immunhamatologie
JID - 101176417
PMC - PMC4086760
OTO - NOTNLM
OT  - Apheresis platelet concentrates
OT  - Gamma irradiation
OT  - Hemostatic function
OT  - Thrombocytopenic patients
OT  - Transfusion efficacy
EDAT- 2014/07/24 06:00
MHDA- 2014/07/24 06:01
PMCR- 2014/05/22
CRDT- 2014/07/24 06:00
PHST- 2014/02/28 00:00 [received]
PHST- 2014/05/12 00:00 [accepted]
PHST- 2014/07/24 06:00 [entrez]
PHST- 2014/07/24 06:00 [pubmed]
PHST- 2014/07/24 06:01 [medline]
PHST- 2014/05/22 00:00 [pmc-release]
AID - tmh-0041-0189 [pii]
AID - 10.1159/000363523 [doi]
PST - ppublish
SO  - Transfus Med Hemother. 2014 Jun;41(3):189-96. doi: 10.1159/000363523. Epub 2014 
      May 22.