PMID- 25054143
OWN - NLM
STAT- MEDLINE
DCOM- 20150929
LR  - 20211021
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2014
DP  - 2014
TI  - Increased oxidative damage associated with unfavorable cytogenetic subgroups in 
      chronic lymphocytic leukemia.
PG  - 686392
LID - 10.1155/2014/686392 [doi]
LID - 686392
AB  - Oxidative stress contributes to genomic instability in chronic lymphocytic 
      leukemia (CLL), but its relationship with the acquisition of specific chromosomal 
      abnormalities is unknown. We recruited 55 untreated CLL patients and assessed 
      8-oxo-2'-deoxyguanosine (8-oxo-dG), glutathione, and malondialdehyde (MDA) 
      levels, and we compared them among the cytogenetic subgroups established using 
      fluorescence in situ hybridization (FISH). Significant increases in 8-oxo-dG 
      and/or MDA were observed in patients with unfavorable cytogenetic aberrations 
      (17p and 11q deletions) compared to the 13q deletion group. TP53 deletion 
      patients exhibited a diminished DNA repair efficiency. Finally, cases with normal 
      FISH also showed enhanced 8-oxo-dG, which could result in adverse outcomes.
FAU - Collado, Rosa
AU  - Collado R
AUID- ORCID: 0000-0002-8205-6192
AD  - Service of Hematology, CDB-University General Hospital of Valencia, Avenida Tres 
      Cruces 2, 46014 Valencia, Spain.
FAU - Ivars, David
AU  - Ivars D
AUID- ORCID: 0000-0003-3766-1606
AD  - Department of Medicine, Faculty of Medicine, University of Valencia, Avenida 
      Blasco Ibanez 13, 46010 Valencia, Spain.
FAU - Oliver, Isabel
AU  - Oliver I
AUID- ORCID: 0000-0002-4503-3303
AD  - Department of Medicine, Faculty of Medicine, University of Valencia, Avenida 
      Blasco Ibanez 13, 46010 Valencia, Spain.
FAU - Tormos, Carmen
AU  - Tormos C
AD  - CIBERobn, Biomedical Network Research Centre in Physiopathology of Obesity and 
      Nutrition, Choupana s/n, 15706 Santiago de Compostela, Spain.
FAU - Egea, Mercedes
AU  - Egea M
AUID- ORCID: 0000-0002-1510-529X
AD  - Service of Hematology, CDB-University General Hospital of Valencia, Avenida Tres 
      Cruces 2, 46014 Valencia, Spain.
FAU - Miguel, Amparo
AU  - Miguel A
AUID- ORCID: 0000-0003-3390-9926
AD  - Service of Hematology, CDB-University General Hospital of Valencia, Avenida Tres 
      Cruces 2, 46014 Valencia, Spain.
FAU - Saez, Guillermo T
AU  - Saez GT
AD  - CIBERobn, Biomedical Network Research Centre in Physiopathology of Obesity and 
      Nutrition, Choupana s/n, 15706 Santiago de Compostela, Spain ; Department of 
      Biochemistry and Molecular Biology, Faculty of Medicine, University of Valencia, 
      Avenida Blasco Ibanez 13, 46010 Valencia, Spain ; Service of Clinical Analyses, 
      CDB-University General Hospital of Valencia, Avenida Tres Cruces 2, 46014 
      Valencia, Spain.
FAU - Carbonell, Felix
AU  - Carbonell F
AD  - Service of Hematology, CDB-University General Hospital of Valencia, Avenida Tres 
      Cruces 2, 46014 Valencia, Spain ; Department of Medicine, Faculty of Medicine, 
      University of Valencia, Avenida Blasco Ibanez 13, 46010 Valencia, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140626
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Reactive Oxygen Species)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
RN  - G9481N71RO (Deoxyguanosine)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - 8-Hydroxy-2'-Deoxyguanosine
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - Cohort Studies
MH  - DNA Damage
MH  - DNA Repair
MH  - Deoxyguanosine/analogs & derivatives/chemistry
MH  - Female
MH  - Gene Deletion
MH  - Glutathione/chemistry
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
MH  - Lipid Peroxidation
MH  - Lymphocytes/drug effects
MH  - Male
MH  - Malondialdehyde/chemistry
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Reactive Oxygen Species
PMC - PMC4099055
EDAT- 2014/07/24 06:00
MHDA- 2015/09/30 06:00
PMCR- 2014/06/26
CRDT- 2014/07/24 06:00
PHST- 2014/02/16 00:00 [received]
PHST- 2014/05/30 00:00 [revised]
PHST- 2014/06/11 00:00 [accepted]
PHST- 2014/07/24 06:00 [entrez]
PHST- 2014/07/24 06:00 [pubmed]
PHST- 2015/09/30 06:00 [medline]
PHST- 2014/06/26 00:00 [pmc-release]
AID - 10.1155/2014/686392 [doi]
PST - ppublish
SO  - Biomed Res Int. 2014;2014:686392. doi: 10.1155/2014/686392. Epub 2014 Jun 26.