PMID- 25054402
OWN - NLM
STAT- MEDLINE
DCOM- 20141105
LR  - 20220321
IS  - 2150-1149 (Electronic)
IS  - 1533-3159 (Linking)
VI  - 17
IP  - 4
DP  - 2014 Jul-Aug
TI  - Human umbilical cord mesenchymal stem cell transplantation for the treatment of 
      chronic discogenic low back pain.
PG  - E525-30
AB  - BACKGROUND: Chronic low back pain is one of the major causes of disability and 
      thus has a major socioeconomic impact. Intervertebral disc degeneration is the 
      main cause of chronic low back pain. Treatment for chronic discogenic low back 
      pain has traditionally been limited to either conservative management or surgical 
      fusion. If conservative treatment fails, then surgical fusion is commonly 
      considered. Current treatments are limited to treat the symptoms and not the 
      underlying biologic alterations of the disc. OBJECTIVE: Human umbilical cord 
      tissue-derived mesenchymal stem cells (HUC-MSCs) contain stem cells and possess 
      the ability to regenerate degenerative discs. Based on the results of previous in 
      vitro and animal experiments, we conducted a preliminary study to test the 
      feasibility and safety and to obtain an early indication for the therapeutic 
      value of HUC-MSC transplantation in patients with chronic discogenic low back 
      pain. STUDY DESIGN: This is the first study involving treatment of chronic low 
      back pain using HUC-MSC transplantation. SETTING: The study was performed at a 
      spine center in China. METHODS: Two patients with chronic discogenic low back 
      pain were treated with HUC-MSC transplantation. An 11-point visual analog scale 
      (VAS, 0-10) and Oswestry Disability Index (ODI, 0-100) were used to assess the 
      back pain symptoms and the lumbar function, respectively. RESULTS: After 
      transplantation, the pain and function improved immediately in the 2 patients. 
      The VAS and ODI scores decreased obviously during a 2-year follow-up period. 
      LIMITATIONS: The shortcoming of this study is that it is a preliminary study with 
      only 2 patients. CONCLUSION: The clinical outcomes indicated that HUC-MSC 
      transplantation is a favorable alternative method for the treatment of chronic 
      discogenic low back pain.
FAU - Pang, Xiaodong
AU  - Pang X
FAU - Yang, Hong
AU  - Yang H
FAU - Peng, Baogan
AU  - Peng B
AD  - The Department of Spinal Surgery, General Hospital of Armed Police Force, 
      Beijing, China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Pain Physician
JT  - Pain physician
JID - 100954394
SB  - IM
MH  - Adult
MH  - Chronic Pain
MH  - *Cord Blood Stem Cell Transplantation
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Intervertebral Disc Degeneration/*surgery
MH  - Low Back Pain/etiology/*surgery
MH  - Lumbar Vertebrae
MH  - Male
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Middle Aged
EDAT- 2014/07/24 06:00
MHDA- 2014/11/06 06:00
CRDT- 2014/07/24 06:00
PHST- 2014/07/24 06:00 [entrez]
PHST- 2014/07/24 06:00 [pubmed]
PHST- 2014/11/06 06:00 [medline]
PST - ppublish
SO  - Pain Physician. 2014 Jul-Aug;17(4):E525-30.