PMID- 25054870
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20191210
IS  - 1678-2674 (Electronic)
IS  - 0102-8650 (Linking)
VI  - 29
IP  - 7
DP  - 2014 Jul
TI  - Effects of enoxaparin and unfractionated heparin in prophylactic and therapeutic 
      doses on the fertility of female Wistar rats.
PG  - 410-6
LID - S0102-86502014000700410 [pii]
AB  - PURPOSE: To evaluate the effects of exposure of enoxaparin and unfractionated 
      heparin (UFH) in prophylactic and therapeutic doses on the fertility rates of 
      pregnant healthy Wistar rats. METHODS: Enoxaparin and UFH were administered in 
      prophylactic doses 1 mg/Kg/day 72 UI/Kg/day, and in therapeutic doses at 2 
      mg/kg/day 400UI/Kg/day. The rats were divided into five groups. The number of 
      live and dead foetuses was quantified. The uterine horns were dissected and the 
      presence of early and late reabsorptions (abortions) was determined. A p<0.05 was 
      considered statistically significant. RESULTS: We did not observe statistically 
      significant differences between groups when comparing the average weight of the 
      foetuses and placentas, rate of female VS males, rates of pre-implantation loss 
      (RPL), rates of efficiency implantation (REI), rates of post-implantation loss 
      (RPIL) and rates of foetal viability (RFV). CONCLUSIONS: There was no significant 
      effect on fertility with the use of anticoagulant drugs in pregnant healthy 
      Wistar rats.
FAU - Figueiro-Filho, Ernesto Antonio
AU  - Figueiro-Filho EA
AD  - Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
FAU - Aydos, Ricardo Dutra
AU  - Aydos RD
AD  - FAMED, UFMS, Campo Grande, MS, Brazil.
FAU - Senefonte, Flavio Renato de Almeida
AU  - Senefonte FR
AD  - FAMED, UFMS, Campo Grande, MS, Brazil.
FAU - Ferreira, Cristiane Munaretto
AU  - Ferreira CM
AD  - FAMED, UFMS, Campo Grande, MS, Brazil.
FAU - Pereira, Erica Freire de Vasconcelos
AU  - Pereira EF
AD  - FAMED, UFMS, Campo Grande, MS, Brazil.
FAU - Oliveira, Vanessa Marcon de
AU  - Oliveira VM
AD  - FAMED, UFMS, Campo Grande, MS, Brazil.
FAU - Menezes, Giovanna Padoa de
AU  - Menezes GP
AD  - FAMED, UFMS, Campo Grande, MS, Brazil.
FAU - Bosio, Marco Antonio Costa
AU  - Bosio MA
AD  - FAMED, UFMS, Campo Grande, MS, Brazil.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - Brazil
TA  - Acta Cir Bras
JT  - Acta cirurgica brasileira
JID - 9103983
RN  - 0 (Anticoagulants)
RN  - 0 (Enoxaparin)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Animals
MH  - Anticoagulants/*administration & dosage/adverse effects
MH  - Enoxaparin/*administration & dosage/adverse effects
MH  - Female
MH  - Fertility/*drug effects
MH  - Fetus/drug effects
MH  - Hemorrhage/chemically induced
MH  - Heparin/*administration & dosage/adverse effects
MH  - Male
MH  - Placenta/drug effects
MH  - Pregnancy
MH  - Random Allocation
MH  - Rats, Wistar
MH  - Reference Values
MH  - Thromboembolism/drug therapy
MH  - Time Factors
EDAT- 2014/07/24 06:00
MHDA- 2015/04/07 06:00
CRDT- 2014/07/24 06:00
PHST- 2014/02/17 00:00 [received]
PHST- 2014/05/22 00:00 [accepted]
PHST- 2014/07/24 06:00 [entrez]
PHST- 2014/07/24 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
AID - S0102-86502014000700410 [pii]
AID - 10.1590/s0102-86502014000700001 [doi]
PST - ppublish
SO  - Acta Cir Bras. 2014 Jul;29(7):410-6. doi: 10.1590/s0102-86502014000700001.