PMID- 25055143
OWN - NLM
STAT- MEDLINE
DCOM- 20150407
LR  - 20211021
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 25
IP  - 13
DP  - 2014 Sep 10
TI  - Effect of local application of an antibody against brain-derived neurotrophic 
      factor on neuroma formation after transection of the inferior alveolar nerve in 
      the rat.
PG  - 1069-74
LID - 10.1097/WNR.0000000000000231 [doi]
AB  - This study aimed to examine the contributions of brain-derived neurotrophic 
      factor (BDNF) at the injury site toward neuroma formation and nerve regeneration 
      after inferior alveolar nerve transection. Histological analysis confirmed 
      neuroma formation at 2 weeks after complete transection of the inferior alveolar 
      nerve. A local administration of an antibody to BDNF inhibited connective tissue 
      proliferation at the injury site and promoted nerve fiber integrity. Fluorogold 
      labeling showed a significantly higher number of labeled cells in the trigeminal 
      ganglion in the anti-BDNF-treated group compared with the vehicle control group. 
      In-situ hybridization histochemistry showed intense signals for tropomyosin 
      receptor kinase B mRNA in the area of the injury site containing fibrous or 
      granular tissue in the anti-BDNF-treated group. In contrast, these signals were 
      close to the detection limit in the area of the perineurium in intact nerve 
      trunks, indicating that the signals were expressed by fibroblasts within the 
      connective tissue. These findings suggest that antagonization of endogenous BDNF 
      induced by nerve injury reduces neuroma formation, without inhibiting damaged 
      axon regeneration.
FAU - Valverde Guevara, Yessenia M
AU  - Valverde Guevara YM
AD  - aDivision of Oral Anatomy bDivision of Orthodontics cDivision of Dental 
      Anesthesiology, Niigata University Graduate School of Medical and Dental 
      Sciences, Niigata, Japan.
FAU - Yoshikawa, Hiroyuki
AU  - Yoshikawa H
FAU - Saito, Isao
AU  - Saito I
FAU - Maeda, Takeyasu
AU  - Maeda T
FAU - Seo, Kenji
AU  - Seo K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt)
RN  - 0 (Antibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Stilbamidines)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Antibodies/administration & dosage
MH  - Brain-Derived Neurotrophic Factor/immunology/*metabolism
MH  - Cranial Nerve Neoplasms/etiology/pathology/*physiopathology
MH  - Fibroblasts/pathology/physiology
MH  - In Situ Hybridization
MH  - Male
MH  - Mandibular Nerve/pathology/*physiopathology
MH  - Nerve Regeneration/*physiology
MH  - Neuroma/etiology/pathology/*physiopathology
MH  - RNA, Messenger/metabolism
MH  - Random Allocation
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/metabolism
MH  - Stilbamidines
MH  - Trigeminal Nerve Injuries/complications/pathology/*physiopathology
PMC - PMC4162327
EDAT- 2014/07/24 06:00
MHDA- 2015/04/08 06:00
CRDT- 2014/07/24 06:00
PHST- 2014/07/24 06:00 [entrez]
PHST- 2014/07/24 06:00 [pubmed]
PHST- 2015/04/08 06:00 [medline]
AID - 10.1097/WNR.0000000000000231 [doi]
PST - ppublish
SO  - Neuroreport. 2014 Sep 10;25(13):1069-74. doi: 10.1097/WNR.0000000000000231.