PMID- 25056074
OWN - NLM
STAT- MEDLINE
DCOM- 20150401
LR  - 20191112
IS  - 1884-2836 (Electronic)
IS  - 1344-6304 (Linking)
VI  - 67
IP  - 4
DP  - 2014
TI  - A novel complex recombinant form of type 48-related human adenovirus species D 
      isolated in Japan.
PG  - 282-7
AB  - Recently, new genotypes of human adenoviruses (HAdVs) have been reported and many 
      of them have been found to be recombinant forms of different known types of HAdV 
      species D (HAdV-D). The objective of this study was to document the evolutionary 
      features of a novel isolate (HAdV_Chiba_E086/2012) obtained from the eye swab of 
      a patient with conjunctivitis in Japan. Viral DNA was extracted from the isolate 
      to sequence the whole genome by the Sanger method and aligned with available 
      genome sequences of HAdV-Ds. The phylogenetic trees of the nucleotide sequences 
      of the penton base, hexon, and fiber genes and the E3 region showed that 
      HAdV_Chiba_E086/2012 is closest to HAdV genotype 65 (HAdV-GT65), HAdV-48, 
      HAdV-GT60 and HAdV-22 at 98%, 99%, 95% and 98% identity, respectively, suggesting 
      that this isolate is a novel recombinant form to be designated as P65H48F60. 
      Further phylogenetic and recombination analyses of the genome alignment of the 
      new isolate implied that nested recombination events involving HAdV-GT59, GT65, 
      48, GT60, 22, and some ancestral lineages or their close relatives have shaped 
      its genome. These results showed that HAdV_Chiba_E086/2012 is the first 
      HAdV-48-related HAdV found in Japan, which has the most complicated evolutionary 
      history among the known HAdVs so far.
FAU - Fujimoto, Tsuguto
AU  - Fujimoto T
AD  - National Institute of Infectious Diseases.
FAU - Yamane, Shotaro
AU  - Yamane S
FAU - Ogawa, Tomoko
AU  - Ogawa T
FAU - Hanaoka, Nozomu
AU  - Hanaoka N
FAU - Ogura, Atsushi
AU  - Ogura A
FAU - Hotta, Chiemi
AU  - Hotta C
FAU - Niwa, Takeshi
AU  - Niwa T
FAU - Chiba, Yakou
AU  - Chiba Y
FAU - Gonzalez, Gabriel
AU  - Gonzalez G
FAU - Aoki, Koki
AU  - Aoki K
FAU - Koyanagi, Kanako Ono
AU  - Koyanagi KO
FAU - Watanabe, Hidemi
AU  - Watanabe H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Infect Dis
JT  - Japanese journal of infectious diseases
JID - 100893704
RN  - 0 (DNA, Viral)
SB  - IM
EIN - Jpn J Infect Dis. 2014;67(5):416
MH  - Adenovirus Infections, Human/*virology
MH  - Adenoviruses, Human/classification/*genetics/isolation & purification
MH  - DNA, Viral/analysis/genetics
MH  - Female
MH  - Humans
MH  - Japan
MH  - Middle Aged
MH  - Phylogeny
MH  - Recombination, Genetic
MH  - Sequence Analysis, DNA
EDAT- 2014/07/25 06:00
MHDA- 2015/04/02 06:00
CRDT- 2014/07/25 06:00
PHST- 2014/07/25 06:00 [entrez]
PHST- 2014/07/25 06:00 [pubmed]
PHST- 2015/04/02 06:00 [medline]
AID - DN/JST.JSTAGE/yoken/67.282 [pii]
AID - 10.7883/yoken.67.282 [doi]
PST - ppublish
SO  - Jpn J Infect Dis. 2014;67(4):282-7. doi: 10.7883/yoken.67.282.