PMID- 25056779
OWN - NLM
STAT- MEDLINE
DCOM- 20150604
LR  - 20210716
IS  - 1880-3989 (Electronic)
IS  - 0388-1350 (Linking)
VI  - 39
IP  - 4
DP  - 2014 Aug
TI  - Immunosuppressive potential of bardoxolone methyl using a modified murine local 
      lymph node assay (LLNA).
PG  - 545-50
AB  - 2-Cyano-3, 12-dioxooleana-1, 9-dien-28-oic acid methyl ester (CDDO-Me; 
      bardoxolone methyl) is one of the synthetic oleanane triterpenoids (SOs). It is 
      known that it is the strongest Nrf2/ARE signaling inducer of SOs and slightly 
      inhibits immune response. Little was known about the immunomodulatory action of 
      CDDO-Me in vivo. We assessed its immunosuppressive potential by using the 
      modified mouse lymph node assay (LLNA) including immunosuppression-related gene 
      expression analysis. In the modified LLNA, CDDO-Me showed a significant decrease 
      in lymph node weight and changes in expressions of the immunosuppression-related 
      genes, Zfp459 and Fmo2. It has been already reported that a decrease in lymph 
      node weight was induced by several types of immunosuppressive chemicals such as 
      calcineurin inhibitors, antimetabolites, steroids, and alkylators. In addition, 
      changes in Zfp459 and Fmo2 expression was reported in response after only 
      treatment of antimetabolites. From these results, CDDO-Me is considered to have 
      an immunosuppressive action and similar mechanism to antimetabolites.
FAU - Kitsukawa, Mika
AU  - Kitsukawa M
AD  - Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research 
      Laboratories, Toray Industries, Inc.
FAU - Tsuchiyama, Hiromi
AU  - Tsuchiyama H
FAU - Maeda, Akihisa
AU  - Maeda A
FAU - Oshida, Keiyu
AU  - Oshida K
FAU - Miyamoto, Yohei
AU  - Miyamoto Y
LA  - eng
PT  - Letter
PL  - Japan
TA  - J Toxicol Sci
JT  - The Journal of toxicological sciences
JID - 7805798
RN  - 0 (Antimetabolites)
RN  - 0 (Immunosuppressive Agents)
RN  - 6SMK8R7TGJ (Oleanolic Acid)
RN  - CEG1Q6OGU1 (bardoxolone methyl)
RN  - EC 1.13.- (Oxygenases)
RN  - EC 1.14.13.8 (dimethylaniline monooxygenase (N-oxide forming))
SB  - IM
MH  - Animals
MH  - Antimetabolites
MH  - Female
MH  - Gene Expression/drug effects
MH  - Immune Tolerance/genetics
MH  - *Immunosuppressive Agents
MH  - *Local Lymph Node Assay
MH  - Lymph Nodes/drug effects
MH  - Mice, Inbred BALB C
MH  - Oleanolic Acid/*analogs & derivatives/pharmacology
MH  - Organ Size/drug effects
MH  - Oxygenases
EDAT- 2014/07/25 06:00
MHDA- 2015/06/05 06:00
CRDT- 2014/07/25 06:00
PHST- 2014/07/25 06:00 [entrez]
PHST- 2014/07/25 06:00 [pubmed]
PHST- 2015/06/05 06:00 [medline]
AID - DN/JST.JSTAGE/jts/39.545 [pii]
AID - 10.2131/jts.39.545 [doi]
PST - ppublish
SO  - J Toxicol Sci. 2014 Aug;39(4):545-50. doi: 10.2131/jts.39.545.