PMID- 25057446
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2162-4011 (Print)
IS  - 2162-402X (Electronic)
IS  - 2162-4011 (Linking)
VI  - 3
DP  - 2014
TI  - A clinically useful approach to enhance immunological memory and antitumor 
      immunity.
PG  - e28811
LID - e28811
AB  - Persistence of vaccine-induced immune responses, not the initial magnitude, best 
      correlates with protective antitumor immunity. In mice, oligonucleotide 
      aptamer-targeted siRNA inhibition of mammalian target of rapamycin (mTOR) 
      activity in activated CD8+ T cells promotes their differentiation into 
      functionally competent memory cells leading to enhanced antitumor immunity, a 
      protective effect superior to that of non-targeted administration of the mTOR 
      inhibitor rapamycin.
FAU - Berezhnoy, Alex
AU  - Berezhnoy A
AD  - Department of Microbiology & Immunology; Dodson Interdisciplinary Immunotherapy 
      Institute; Sylvester Comprehensive Cancer Center; Miller School of Medicine; 
      University of Miami; Miami, FL USA.
FAU - Rajagopalan, Anugraha
AU  - Rajagopalan A
AD  - Department of Microbiology & Immunology; Dodson Interdisciplinary Immunotherapy 
      Institute; Sylvester Comprehensive Cancer Center; Miller School of Medicine; 
      University of Miami; Miami, FL USA.
FAU - Gilboa, Eli
AU  - Gilboa E
AD  - Department of Microbiology & Immunology; Dodson Interdisciplinary Immunotherapy 
      Institute; Sylvester Comprehensive Cancer Center; Miller School of Medicine; 
      University of Miami; Miami, FL USA.
LA  - eng
GR  - R01 CA181598/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20140514
PL  - United States
TA  - Oncoimmunology
JT  - Oncoimmunology
JID - 101570526
PMC - PMC4091317
OTO - NOTNLM
OT  - 4-1BB costimulation
OT  - T cell memory
OT  - Tumor immunity
OT  - aptamers
OT  - mTOR
EDAT- 2014/07/25 06:00
MHDA- 2014/07/25 06:01
PMCR- 2014/05/14
CRDT- 2014/07/25 06:00
PHST- 2014/03/31 00:00 [received]
PHST- 2014/04/07 00:00 [accepted]
PHST- 2014/07/25 06:00 [entrez]
PHST- 2014/07/25 06:00 [pubmed]
PHST- 2014/07/25 06:01 [medline]
PHST- 2014/05/14 00:00 [pmc-release]
AID - 2014ONCOIMM0097 [pii]
AID - 10.4161/onci.28811 [doi]
PST - epublish
SO  - Oncoimmunology. 2014 May 14;3:e28811. doi: 10.4161/onci.28811. eCollection 2014.