PMID- 25059577
OWN - NLM
STAT- MEDLINE
DCOM- 20160414
LR  - 20220408
IS  - 1089-4098 (Electronic)
IS  - 1073-8584 (Linking)
VI  - 21
IP  - 4
DP  - 2015 Aug
TI  - Post-Traumatic Brain Injury: Genetic Susceptibility to Outcome.
PG  - 424-41
LID - 10.1177/1073858414543150 [doi]
AB  - It is estimated that 2% of the population from industrialized countries live with 
      lifelong disabilities resulting from traumatic brain injury (TBI) and roughly one 
      in four adults are unable to return to work 1 year after injury because of 
      physical or mental disabilities. TBI is a significant public health issue that 
      causes substantial physical and economical repercussions for the individual and 
      society. Electronic databases (PubMed, Web of Science, Google Scholar) were 
      searched with the keywords traumatic brain injury, TBI, genes and TBI, TBI 
      outcome, head injury. Human studies on non-penetrating traumatic brain injuries 
      reported in English were included. To provide health care workers with the basic 
      information for clinical management we summarize and compare the data on post-TBI 
      outcome with regard to the impact of genetic variation: apolipoprotein E (APOE), 
      brain-derived neurotrophic factor (BDNF), calcium channel, voltage dependent P/Q 
      type, catechol-O-methyltransferase (COMT), dopamine receptor D2 and ankyrin 
      repeat and kinase domain containing 1 (DRD2 and ANKK1), interleukin-1 (IL-1), 
      interleukin-6 (IL-6), kidney and brain expressed protein (KIBRA), neurofilament, 
      heavy polypeptide (NEFH), endothelial nitric oxide synthase 3 (NOS3), poly 
      (ADP-ribose) polymerase-1 (PARP-1), protein phosphatase 3, catalytic subunit, 
      gamma isozyme (PPP3CC), the serotonin transporter (5-HTT) gene solute carrier 
      family 6 member (SLC6A4) and tumor protein 53 (TP53). It is evident that 
      contradicting results are attributable to the heterogeneity of studies, thus 
      further researches are warranted to effectively assess a relation between genetic 
      traits and clinical outcome following traumatic injuries.
CI  - (c) The Author(s) 2014.
FAU - Davidson, Jennilee
AU  - Davidson J
AD  - Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, 
      Ontario, Canada Deparment of Biology, Queen's University, Kingston, Ontario, 
      Canada 8jmd@queensu.ca.
FAU - Cusimano, Michael D
AU  - Cusimano MD
AD  - Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, 
      Ontario, Canada.
FAU - Bendena, William G
AU  - Bendena WG
AD  - Deparment of Biology, Queen's University, Kingston, Ontario, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140724
PL  - United States
TA  - Neuroscientist
JT  - The Neuroscientist : a review journal bringing neurobiology, neurology and 
      psychiatry
JID - 9504819
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain Injuries/*genetics/metabolism/*therapy
MH  - Child
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Recovery of Function
MH  - Risk Factors
MH  - Signal Transduction/*genetics
MH  - Young Adult
OTO - NOTNLM
OT  - apolipoprotein E
OT  - genes and TBI
OT  - head injury
OT  - outcome
OT  - traumatic brain injury (TBI)
EDAT- 2014/07/26 06:00
MHDA- 2016/04/15 06:00
CRDT- 2014/07/26 06:00
PHST- 2014/07/26 06:00 [entrez]
PHST- 2014/07/26 06:00 [pubmed]
PHST- 2016/04/15 06:00 [medline]
AID - 1073858414543150 [pii]
AID - 10.1177/1073858414543150 [doi]
PST - ppublish
SO  - Neuroscientist. 2015 Aug;21(4):424-41. doi: 10.1177/1073858414543150. Epub 2014 
      Jul 24.