PMID- 25060242
OWN - NLM
STAT- MEDLINE
DCOM- 20150619
LR  - 20150418
IS  - 1464-410X (Electronic)
IS  - 1464-4096 (Linking)
VI  - 115
IP  - 5
DP  - 2015 May
TI  - Transient receptor potential channel modulators as pharmacological treatments for 
      lower urinary tract symptoms (LUTS): myth or reality?
PG  - 686-97
LID - 10.1111/bju.12876 [doi]
AB  - Transient receptor potential (TRP) channels belong to the most intensely pursued 
      drug targets of the last decade. These ion channels are considered promising 
      targets for the treatment of pain, hypersensitivity disorders and lower urinary 
      tract symptoms (LUTS). The aim of the present review is to discuss to what extent 
      TRP channels have adhered to their promise as new pharmacological targets in the 
      lower urinary tract (LUT) and to outline the challenges that lie ahead. TRP 
      vanilloid 1 (TRPV1) agonists have proven their efficacy in the treatment of 
      neurogenic detrusor overactivity (DO), albeit at the expense of prolonged adverse 
      effects as pelvic 'burning' pain, sensory urgency and haematuria. TRPV1 
      antagonists have been very successful in preclinical studies to treat pain and 
      DO. However, clinical trials with the first generation TRPV1 antagonists were 
      terminated early due to hyperthermia, a serious, on-target, side-effect. TRP 
      vanilloid 4 (TRPV4), TRP ankyrin 1 (TRPA1) and TRP melastatin 8 (TRPM8) have 
      important sensory functions in the LUT. Antagonists of these channels have shown 
      their potential in pre-clinical studies of LUT dysfunction and are awaiting 
      clinical validation.
CI  - (c) 2014 The Authors. BJU International (c) 2014 BJU International.
FAU - Deruyver, Yves
AU  - Deruyver Y
AD  - Laboratory of Experimental Urology, Department of Development and Regeneration, 
      KU Leuven, Leuven, Belgium; University Hospitals Leuven, Leuven, Belgium; TRP 
      Research Platform Leuven (TRPLe), Leuven, Belgium.
FAU - Voets, Thomas
AU  - Voets T
FAU - De Ridder, Dirk
AU  - De Ridder D
FAU - Everaerts, Wouter
AU  - Everaerts W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150121
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
RN  - 0 (Transient Receptor Potential Channels)
SB  - IM
CIN - BJU Int. 2015 May;115(5):676-7. PMID: 25885558
MH  - Humans
MH  - Lower Urinary Tract Symptoms/*drug therapy
MH  - Transient Receptor Potential Channels/*agonists/*antagonists & inhibitors
OTO - NOTNLM
OT  - LUTS
OT  - TRP channel
OT  - TRPV1
OT  - TRPV4
OT  - afferent nerve
OT  - detrusor overactivity
OT  - urothelium
EDAT- 2014/07/26 06:00
MHDA- 2015/06/20 06:00
CRDT- 2014/07/26 06:00
PHST- 2014/07/26 06:00 [entrez]
PHST- 2014/07/26 06:00 [pubmed]
PHST- 2015/06/20 06:00 [medline]
AID - 10.1111/bju.12876 [doi]
PST - ppublish
SO  - BJU Int. 2015 May;115(5):686-97. doi: 10.1111/bju.12876. Epub 2015 Jan 21.