PMID- 25060517 OWN - NLM STAT- MEDLINE DCOM- 20151208 LR - 20211021 IS - 1435-1250 (Electronic) IS - 0340-1855 (Linking) VI - 74 IP - 2 DP - 2015 Mar TI - Meta-analysis of the association between functional MICA-TM polymorphisms and systemic lupus erythematosus, rheumatoid arthritis and ankylosing spondylitis. PG - 146-52 LID - 10.1007/s00393-014-1409-9 [doi] AB - OBJECTIVE: The aim of this study was to determine whether the major histocompatibility complex class I chain-related gene A transmembrane (MICA-TM) polymorphism is associated with susceptibility to systemic lupus erythematous (SLE), rheumatoid arthritis (RA) and ankylosing spondylitis (AS). METHODS: A meta-analysis was conducted to establish the association between MICA-TM polymorphisms and SLE, RA and AS in the overall study population, as well as in each ethnic group. RESULTS: A total of 13 comparison studies, including five SLE (1601 patients; 1846 controls), four RA (701 patients; 887 controls) and four AS (346 patients; 356 controls) studies were considered in the meta-analysis. An association between the MICA-TM A5.1 allele and SLE was demonstrated in Europeans but not in Asians: odds ratio (OR) = 1.699, 95 % confidence interval (CI) = 1.123-2.569, p = 0.012 and OR = 0.949, 95 % CI = 0.502-1.793, p = 0.871, respectively. However, no association was found in Europeans after Bonferroni correction (pcorrected = 0.060). An association was found between the MICA-TM A9 allele and RA in Asians (OR = 0.527, 95 % CI = 0.408-0.681, p = 8.9 x 10(-7)) but not in Europeans; the association in Asians remained significant after Bonferroni correction (pcorrected = 4.5 x 10(-6)). An association between the MICA-TM A4 phenotype and AS was observed in European and Asian populations (OR = 12.87, 95 % CI = 6.747-24.58, p < 1.0 x 10(-9) and OR = 9.461, 95 % CI = 5.754-15.55, p < 1.0 x 10(-9), respectively). Meta-analysis stratified by human leukocyte antigen (HLA)-B27 status revealed an association between the MICA-TM A4 phenotype and HLA-B27 positivity AS in Asians, but not in Europeans (OR = 0.318, 95 % CI = 0.102-0.995, p = 0.049 and OR = 2.080, 95 % CI = 0.422-10.25, p = 0.368, respectively). However, the association in Asians was not significant after Bonferroni correction (pcorrected = 0.245). CONCLUSION: This meta-analysis demonstrated that there was no association between MICA-TM polymorphisms and SLE susceptibility, but that the MICA-TM A9 allele was associated with an RA risk in Asians. Moreover, the association between the MICA-TM A4 phenotype and AS was HLA-B27-dependent. FAU - Lee, Y H AU - Lee YH AD - Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, 136-705, Seoul, Korea, lyhcgh@korea.ac.kr. FAU - Bae, S-C AU - Bae SC FAU - Kim, J-H AU - Kim JH FAU - Song, G G AU - Song GG LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PL - Germany TA - Z Rheumatol JT - Zeitschrift fur Rheumatologie JID - 0414162 RN - 0 (Genetic Markers) RN - 0 (Histocompatibility Antigens Class I) RN - 0 (MHC class I-related chain A) SB - IM MH - Arthritis, Rheumatoid/epidemiology/*genetics MH - Asia/ethnology MH - Europe/ethnology MH - Female MH - Genetic Association Studies/methods MH - Genetic Markers/genetics MH - Genetic Predisposition to Disease/epidemiology/genetics MH - Histocompatibility Antigens Class I/*genetics MH - Humans MH - Incidence MH - Lupus Erythematosus, Systemic/epidemiology/*genetics MH - Male MH - Mutation/genetics MH - Polymorphism, Single Nucleotide/*genetics MH - Risk Factors MH - Spondylitis, Ankylosing/epidemiology/*genetics EDAT- 2014/07/26 06:00 MHDA- 2015/12/15 06:00 CRDT- 2014/07/26 06:00 PHST- 2014/07/26 06:00 [entrez] PHST- 2014/07/26 06:00 [pubmed] PHST- 2015/12/15 06:00 [medline] AID - 10.1007/s00393-014-1409-9 [doi] PST - ppublish SO - Z Rheumatol. 2015 Mar;74(2):146-52. doi: 10.1007/s00393-014-1409-9.