PMID- 25061270
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140725
LR  - 20211021
IS  - 1177-5467 (Print)
IS  - 1177-5483 (Electronic)
IS  - 1177-5467 (Linking)
VI  - 8
DP  - 2014
TI  - Assessment of beta-zone peripapillary atrophy by optical coherence tomography and 
      scanning laser ophthalmoscopy imaging in glaucoma patients.
PG  - 1233-9
LID - 10.2147/OPTH.S55751 [doi]
AB  - PURPOSE: To assess beta-zone peripapillary atrophy (beta-PPA) using spectral domain 
      optical coherence tomography (SD-OCT), scanning laser ophthalmoscopy (SLO), and 
      fundus auto-fluorescence (FAF) imaging in patients with primary open-angle 
      glaucoma with advanced glaucomatous visual field defects. METHODS: A consecutive, 
      prospective series of 82 study eyes with primary open-angle glaucoma were 
      included in this study. All study participants underwent a full ophthalmic 
      examination followed by SD-OCT, wide-field SLO, and FAF imaging of the optic 
      nerve head and the peripapillary region. RESULTS: Eighty-four glaucomatous eyes 
      were included in our prospective study. Correlation analyses for horizontally and 
      vertically obtained beta-PPA for all three imaging modalities (color SLO, FAF, and 
      SD-OCT) revealed highest correlations between FAF and color SLO (Pearson 
      correlation coefficient: 0.904 [P<0.001] for horizontal beta-PPA and 0.786 [P<0.001] 
      for vertical beta-PPA). Bland-Altman plotting revealed highest agreements between 
      color SLO and FAF, with -2.1 pixels +/-1.96 standard deviation (SD) for horizontal 
      beta-PPA, SD: 10.5 pixels and 2.4 pixels +/-1.96 SD for vertical beta-PPA. CONCLUSION: 
      beta-PPA can be assessed using en-face SLO and cross-sectional SD-OCT imaging. 
      Correlation analyses revealed highest correlations between color SLO and FAF 
      imaging, while correlations between SLO and SD-OCT were weak. A more precise 
      structural definition of beta-PPA is needed.
FAU - Seidensticker, Florian
AU  - Seidensticker F
AD  - Department of Ophthalmology, Hannover Medical School, Hannover, Germany.
FAU - Reznicek, Lukas
AU  - Reznicek L
AD  - Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
FAU - Mann, Thomas
AU  - Mann T
AD  - Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
FAU - Hubert, Irene
AU  - Hubert I
AD  - Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
FAU - Kampik, Anselm
AU  - Kampik A
AD  - Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
FAU - Ulbig, Michael
AU  - Ulbig M
AD  - Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
FAU - Hirneiss, Christoph
AU  - Hirneiss C
AD  - Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
FAU - Neubauer, Aljoscha S
AU  - Neubauer AS
AD  - Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
FAU - Kernt, Marcus
AU  - Kernt M
AD  - Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
LA  - eng
PT  - Journal Article
DEP - 20140627
PL  - New Zealand
TA  - Clin Ophthalmol
JT  - Clinical ophthalmology (Auckland, N.Z.)
JID - 101321512
PMC - PMC4085315
OTO - NOTNLM
OT  - FAF
OT  - OCT
OT  - SD-OCT
OT  - SLO
OT  - fundus autofluorescence
OT  - glaucomatous optic neuropathy
EDAT- 2014/07/26 06:00
MHDA- 2014/07/26 06:01
PMCR- 2014/06/27
CRDT- 2014/07/26 06:00
PHST- 2014/07/26 06:00 [entrez]
PHST- 2014/07/26 06:00 [pubmed]
PHST- 2014/07/26 06:01 [medline]
PHST- 2014/06/27 00:00 [pmc-release]
AID - opth-8-1233 [pii]
AID - 10.2147/OPTH.S55751 [doi]
PST - epublish
SO  - Clin Ophthalmol. 2014 Jun 27;8:1233-9. doi: 10.2147/OPTH.S55751. eCollection 
      2014.