PMID- 25061593
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140725
LR  - 20211021
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 10
IP  - 3
DP  - 2014 Jun
TI  - Influence of mild traumatic brain injury during pediatric stage on short-term 
      memory and hippocampal apoptosis in adult rats.
PG  - 148-54
LID - 10.12965/jer.140109 [doi]
AB  - Traumatic brain injury (TBI) is a leading cause of neurological deficit in the 
      brain, which induces short- and long-term brain damage, cognitive impairment 
      with/without structural alteration, motor deficits, emotional problems, and death 
      both in children and adults. In the present study, we evaluated whether mild TBI 
      in childhood causes persisting memory impairment until adulthood. Moreover, we 
      investigated the influence of mild TBI on memory impairment in relation with 
      hippocampal apoptosis. For this, step-down avoidance task, terminal 
      deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay, and 
      immunohistochemistry for caspase-3 were performed. Male Sprague-Dawley rats were 
      used in the experiments. The animals were randomly divided into two groups: 
      sham-operation group and TBI-induction group. The mild TBI model was created with 
      an electromagnetic contusion device activated at a velocity of 3.0 m/sec. The 
      results showed that mild TBI during the pediatric stage significantly decreased 
      memory retention. The numbers of TUNEL-positive and caspase-3-positive cells were 
      increased in the TBI-induction group compared to those in the sham-operation 
      group. Defective memory retention and apoptosis sustained up to the adult stage. 
      The present results shows that mild TBI induces long-lasting cognitive impairment 
      from pediatric to adult stages in rats through the high level of apoptosis. The 
      finding of this study suggests that children with mild TBI may need intensive 
      treatments for the reduction of long-lasting cognitive impairment by secondary 
      neuronal damage.
FAU - Park, Mi-Sook
AU  - Park MS
AD  - Department of Health and Welfare for the Elderly, Graduate School, Daegu Haany 
      University, Gyeongsan, Korea.
FAU - Oh, Hyean-Ae
AU  - Oh HA
AD  - Department of Health and Welfare for the Elderly, Graduate School, Daegu Haany 
      University, Gyeongsan, Korea.
FAU - Ko, Il-Gyu
AU  - Ko IG
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Kim, Sung-Eun
AU  - Kim SE
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Kim, Sang-Hoon
AU  - Kim SH
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Kim, Chang-Ju
AU  - Kim CJ
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Kim, Hyun-Bae
AU  - Kim HB
AD  - Department of Taekwondo, College of Physical Education, Kyung Hee University, 
      Suwon, Korea.
FAU - Kim, Hong
AU  - Kim H
AD  - Department of Oriental Sports Medicine, College of Biomedical Science, Daegu 
      Haany University, Gyeongsan, Korea.
LA  - eng
PT  - Journal Article
DEP - 20140630
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC4106768
OTO - NOTNLM
OT  - Apoptosis
OT  - Hippocampus
OT  - Pediatric stage
OT  - Short-term memory
OT  - Traumatic brain injury
EDAT- 2014/07/26 06:00
MHDA- 2014/07/26 06:01
PMCR- 2014/06/30
CRDT- 2014/07/26 06:00
PHST- 2014/06/04 00:00 [received]
PHST- 2014/06/19 00:00 [accepted]
PHST- 2014/07/26 06:00 [entrez]
PHST- 2014/07/26 06:00 [pubmed]
PHST- 2014/07/26 06:01 [medline]
PHST- 2014/06/30 00:00 [pmc-release]
AID - jer-10-3-148 [pii]
AID - 10.12965/jer.140109 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2014 Jun 30;10(3):148-54. doi: 10.12965/jer.140109. eCollection 
      2014 Jun.