PMID- 25061594
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140725
LR  - 20211021
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 10
IP  - 3
DP  - 2014 Jun
TI  - Treadmill exercise ameliorates disturbance of spatial learning ability in 
      scopolamine-induced amnesia rats.
PG  - 155-61
LID - 10.12965/jer.140110 [doi]
AB  - Alzheimer's disease is the most common neurodegenerative disease and this disease 
      induces progressive loss of memory function Scopolamine is a non-selective 
      muscarinic cholinergic receptor antagonist and it induces impairment of learning 
      ability. Exercise is known to ameliorate memory deficits induced by various brain 
      diseases. In the present study, we investigated the effect of treadmill exercise 
      on spatial learning ability in relation with cell proliferation in the 
      hippocampus using the scopolamine-induced amnesia mice. For the induction of 
      amnesia, 1 mg/kg scopolamine hydrobromide was administered intraperitoneally once 
      a day for 14 days. Morris water maze test for spatial learning ability was 
      conducted. Immonofluorescence for 5-bromo-2-deoxyuri-dine (BrdU) and western blot 
      for brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B 
      (TrkB) were performed. In the present results, scopolamine-induced amnesia mice 
      showed deterioration of spatial learning ability. Inhibition of cell 
      proliferation and suppression of BDNF and TrkB expressions were observed in the 
      scopolamine-induced amnesia mice. Treadmill exercise improved spatial learning 
      ability and increased cell proliferation through activating of BDNF-TrkB pathway 
      in the amnesia mice. These findings offer a possibility that treadmill exercise 
      may provide preventive or therapeutic value for the memory loss induced by 
      variable neurodegenerative diseases including Alzheimer's disease.
FAU - Heo, Yu-Mi
AU  - Heo YM
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Shin, Mal-Soon
AU  - Shin MS
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Kim, Su-Hyun
AU  - Kim SH
AD  - Department of Physical Education, Graduate School, Dankook University, Seoul, 
      Korea.
FAU - Kim, Tae-Wook
AU  - Kim TW
AD  - Department of Physical Education, College of Physical Education, Hanyang 
      University, Seoul, Korea.
FAU - Baek, Sang-Bin
AU  - Baek SB
AD  - Department of Psychiatry, Gangneung Asan Hospital, University of Ulsan College of 
      Medicine, Gangneung, Korea.
FAU - Baek, Seung-Soo
AU  - Baek SS
AD  - Department of Sport & Health Science, College of Natural Science, Sangmyung 
      University, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20140630
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC4106769
OTO - NOTNLM
OT  - Amnesia
OT  - Brain-derived neurotrophic factor
OT  - Cell proliferation
OT  - Scopolamine
OT  - Spatial learning ability
OT  - Treadmill exercise
EDAT- 2014/07/26 06:00
MHDA- 2014/07/26 06:01
PMCR- 2014/06/30
CRDT- 2014/07/26 06:00
PHST- 2014/06/18 00:00 [received]
PHST- 2014/06/19 00:00 [accepted]
PHST- 2014/07/26 06:00 [entrez]
PHST- 2014/07/26 06:00 [pubmed]
PHST- 2014/07/26 06:01 [medline]
PHST- 2014/06/30 00:00 [pmc-release]
AID - jer-10-3-155 [pii]
AID - 10.12965/jer.140110 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2014 Jun 30;10(3):155-61. doi: 10.12965/jer.140110. eCollection 
      2014 Jun.