PMID- 25061595
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140725
LR  - 20211021
IS  - 2288-176X (Print)
IS  - 2288-1778 (Electronic)
IS  - 2288-176X (Linking)
VI  - 10
IP  - 3
DP  - 2014 Jun
TI  - Treadmill exercise improves spatial learning ability by enhancing brain-derived 
      neurotrophic factor expression in the attention-deficit/hyperactivity disorder 
      rats.
PG  - 162-7
LID - 10.12965/jer.140111 [doi]
AB  - Attention-deficit/hyperactivity disorder (ADHD) patients show learning difficulty 
      and impulsiveness. Exercise is known to improve learning ability and memory 
      function. In the present study, we investigated the duration-dependence of the 
      effect of treadmill exercise on spatial learning ability in relation with 
      brain-derived neurotrophic factor (BDNF) expression in ADHD rats. For this study, 
      radial 8-arm maze test and western blot for BDNF and tyrosine kinase B (TrkB) 
      were performed. Spontaneous hypertensive rats were used as the ADHD rats and 
      Wistar-Kyoto rats were used as the control rats. The rats in the exercise groups 
      were forced to run on a treadmill for 10 min, 30 min, and 60 min once a day for 
      28 consecutive days. ADHD rats displayed impairment of spatial learning ability, 
      in contrast treadmill exercise ameliorated impairment of spatial learning 
      ability. Treadmill exercise for 30 min per day showed most potent ameliorating 
      effect on impairment of spatial learning ability. BDNF and TrkB expressions in 
      the hippocampus were decreased in the ADHD rats, in contrast treadmill exercise 
      enhanced BDNF and TrkB expressions. Treadmill exercise for 30 min and for 60 min 
      per day showed enhancing effects on BDNF and TrkB expressions. Treadmill exercise 
      alleviated deficits in the spatial learning ability through enhancing BDNF and 
      TrkB expressions in the ADHD rats. Treadmill exercise for 30 min per day can be 
      considered as the most effective therapeutic modality for the ADHD symptoms.
FAU - Jeong, Hye Im
AU  - Jeong HI
AD  - Department of Physical Education, Graduate School, Sungshin Women's University, 
      Seoul, Korea.
FAU - Ji, Eun-Sang
AU  - Ji ES
AD  - Dartment of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.
FAU - Kim, Su-Hyun
AU  - Kim SH
AD  - Department of Physical Education, Graduate School, Dankook University, Seoul, 
      Korea.
FAU - Kim, Tae-Wook
AU  - Kim TW
AD  - Department of Physical Education, College of Physical Education, Hanyang 
      University, Seoul, Korea.
FAU - Baek, Sang-Bin
AU  - Baek SB
AD  - Department of Psychiatry, Gangneung Asan Hospital, Ulsan University, Gangneung, 
      Korea.
FAU - Choi, Seung Wook
AU  - Choi SW
AD  - Department of Physical Education, Graduate School, Sungshin Women's University, 
      Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20140630
PL  - Korea (South)
TA  - J Exerc Rehabil
JT  - Journal of exercise rehabilitation
JID - 101615171
PMC - PMC4106770
OTO - NOTNLM
OT  - Attention-deficit/hyperactivity disorder
OT  - Brain-derived neurotrophic factor
OT  - Spatial learning ability
OT  - Treadmill exercise
OT  - Tyrosine kinase B
EDAT- 2014/07/26 06:00
MHDA- 2014/07/26 06:01
PMCR- 2014/06/30
CRDT- 2014/07/26 06:00
PHST- 2014/06/12 00:00 [received]
PHST- 2014/06/19 00:00 [accepted]
PHST- 2014/07/26 06:00 [entrez]
PHST- 2014/07/26 06:00 [pubmed]
PHST- 2014/07/26 06:01 [medline]
PHST- 2014/06/30 00:00 [pmc-release]
AID - jer-10-3-162 [pii]
AID - 10.12965/jer.140111 [doi]
PST - epublish
SO  - J Exerc Rehabil. 2014 Jun 30;10(3):162-7. doi: 10.12965/jer.140111. eCollection 
      2014 Jun.