PMID- 25062411
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20211203
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 13
IP  - 3
DP  - 2014 Jul 2
TI  - Genetic diversity of HLA-DRB1 alleles in the Tujia population of Wufeng, Hubei 
      Province, China.
PG  - 4756-65
LID - 10.4238/2014.July.2.5 [doi]
AB  - We established a genetic database by investigating human leukocyte antigen 
      (HLA)-DRB1 allelic frequencies in a disease-association study in the Tujia 
      population in Wufang, Hubei, China. The allele frequencies of the HLA-DRB1 locus 
      in 262 healthy, unrelated Tujia individuals living in the Wufeng region of the 
      Hubei Province were analyzed using the Luminex HLA sequence-specific 
      oligonucleotide method with a WAKFlow HLA typing kit. A total of 13 alleles were 
      detected at the HLA-DRB1 locus. HLA-DRB1*09 was the most common allele (22.52%), 
      followed by DRB1*08 and DRB1*15 (11.07%), and DRB1*12 and DRB1*04 (10.69%). These 
      data were compared with the results obtained for 10 other ethnic groups living in 
      other regions as well as to Han groups using neighbor-joining dendrograms and 
      principal component analysis. The results showed that the Tujia population has a 
      close genetic relationship with the Middle Han population at the HLA-DRB1 locus. 
      This information will be useful for HLA-DRB1-linked disease-association studies.
FAU - Qiu, X P
AU  - Qiu XP
AD  - Institute of Virology, Medical School of Wuhan University, Wuhan, Hubei, China.
FAU - Zhang, L
AU  - Zhang L
AD  - Institute of Virology, Medical School of Wuhan University, Wuhan, Hubei, China.
FAU - Zeng, F Y
AU  - Zeng FY
AD  - The Clinical Laboratory, Wuhan Hospital, Wuhan, China.
FAU - Wen, Y
AU  - Wen Y
AD  - Medical School of Hubei University of Science and Technology, Hubei, China.
FAU - Li, C
AU  - Li C
AD  - Wuhan Nursing Home Hot Spring Rehabilitation Sanitarium Area, Xianning, Hubei, 
      China.
FAU - Qiu, L X
AU  - Qiu LX
AD  - Institute of Virology, Medical School of Wuhan University, Wuhan, Hubei, China.
FAU - Cheng, D X
AU  - Cheng DX
AD  - Department of Medicine and Medical Biophysics, University of Toronto, Toronto, 
      Ontario, Canada.
FAU - Wu, X X
AU  - Wu XX
AD  - Institute of Virology, Medical School of Wuhan University, Wuhan, Hubei, China 
      qiuxp8488@sohu.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140702
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - *Alleles
MH  - China
MH  - *Ethnicity
MH  - Female
MH  - Gene Expression
MH  - Gene Frequency
MH  - *Genetic Loci
MH  - *Genetic Variation
MH  - HLA-DRB1 Chains/classification/*genetics
MH  - Humans
MH  - Leukocytes, Mononuclear/cytology/metabolism
MH  - Male
MH  - Phylogeny
MH  - Poverty
MH  - Principal Component Analysis
EDAT- 2014/07/26 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/07/26 06:00
PHST- 2014/07/26 06:00 [entrez]
PHST- 2014/07/26 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - gmr3970 [pii]
AID - 10.4238/2014.July.2.5 [doi]
PST - epublish
SO  - Genet Mol Res. 2014 Jul 2;13(3):4756-65. doi: 10.4238/2014.July.2.5.