PMID- 25062962
OWN - NLM
STAT- MEDLINE
DCOM- 20151208
LR  - 20230919
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Print)
IS  - 0931-041X (Linking)
VI  - 30
IP  - 4
DP  - 2015 Apr
TI  - HLA sensitisation: can it be prevented?
PG  - 577-87
LID - 10.1007/s00467-014-2868-6 [doi]
AB  - Human leukocyte antigen (HLA) sensitisation occurs after transfusion of blood 
      products and transplantation. It can also happen spontaneously through 
      cross-sensitisation from infection and pro-inflammatory events. Patients who are 
      highly sensitised face longer waiting times on organ allocation programmes, more 
      graft rejection and therefore more side effects of immunosuppression, and poorer 
      graft outcomes. In this review, we discuss these issues, along with the 
      limitations of modern HLA detection methods, and potential ways of decreasing HLA 
      antibody development. We do not discuss the removal of antibodies after they have 
      developed.
FAU - Rees, Lesley
AU  - Rees L
AD  - Department of Paediatric Nephrology, Great Ormond Street Hospital for Children 
      NHS Foundation Trust, Great Ormond Street, London, WC1N 3JH, UK, 
      pediatric_nephrology@ucl.ac.uk.
FAU - Kim, Jon Jin
AU  - Kim JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140726
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Blood Donors
MH  - Child
MH  - Erythrocyte Transfusion
MH  - HLA Antigens/analysis/*immunology
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Isoantibodies/*blood
MH  - *Kidney Transplantation
PMC - PMC4333359
EDAT- 2014/07/27 06:00
MHDA- 2015/12/15 06:00
PMCR- 2014/07/26
CRDT- 2014/07/27 06:00
PHST- 2014/05/01 00:00 [received]
PHST- 2014/05/23 00:00 [accepted]
PHST- 2014/05/22 00:00 [revised]
PHST- 2014/07/27 06:00 [entrez]
PHST- 2014/07/27 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2014/07/26 00:00 [pmc-release]
AID - 2868 [pii]
AID - 10.1007/s00467-014-2868-6 [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2015 Apr;30(4):577-87. doi: 10.1007/s00467-014-2868-6. Epub 2014 
      Jul 26.