PMID- 25063291
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20180219
IS  - 2352-4146 (Electronic)
IS  - 1995-7645 (Linking)
VI  - 7
IP  - 7
DP  - 2014 Jul
TI  - Effect of pharmacological intervention on MIP-1alpha, MIP-1beta and MCP-1 expression in 
      patients with psoriasis vulgaris.
PG  - 582-4
LID - S1995-7645(14)60098-5 [pii]
LID - 10.1016/S1995-7645(14)60098-5 [doi]
AB  - OBJECTIVE: To detect the expression level of macrophage inflammatory protein-1 
      (MIP-1)alpha, MIP-1beta and monocyte chemoattractant protein-1 (MCP-1) in with psoriasis 
      vulgaris and explore the role in the pathogenesis of psoriasis vulgaris. METHODS: 
      The level of MIP-1alpha, MIP-1beta and MCP-1 in peripheral blood from 50 patients with 
      psoriasis vulgaris and 50 normal controls were measured by enzyme linked 
      immunosorbent assay. The correlation with psoriasis area and severity index 
      (PASI) was analyzed. The level of MIP-1alpha, MIP-1beta and MCP-1 was compared between 
      psoriasis vulgaris patients at active stage and resting stage. And the change in 
      MIP-1alpha, MIP-1beta and MCP-1 before and after therapy was also observed. RESULTS: The 
      content of MIP-1alpha, MIP-1beta and MCP-1 in patients with psoriasis vulgaris was 
      (1342.78 +/- 210.30), (175.28 +/- 28.18) and (266.86 +/- 32.75) ng/L, respectively, 
      significantly higher than those in control group (P<0.05). The expression level 
      of MIP-1alpha, MIP-1beta and MCP-1 in peripheral blood of patients with psoriasis 
      vulgaris was positively correlated with PASI (P<0.01). After acitretin therapy, 
      expression level of MIP-1alpha, MIP-1beta and MCP-1 in peripheral blood of patients with 
      psoriasis vulgaris was significantly decreased. CONCLUSIONS: Chemokine factor 
      MIP-1alpha, MIP-1beta and MCP-1 may be involved in the pathogenesis of psoriasis 
      vulgaris.
CI  - Copyright (c) 2014 Hainan Medical College. Published by Elsevier B.V. All rights 
      reserved.
FAU - Dai, Yong-Jiang
AU  - Dai YJ
AD  - Department of Dermatology, Affiliated Hospital of Hainan Medical College, Haikou 
      570102, China.
FAU - Li, Yu-Yang
AU  - Li YY
AD  - Department of Dermatology, Sanya Agricultural Reclamation Hospital, SanYa 57200, 
      China.
FAU - Zeng, Hui-Ming
AU  - Zeng HM
AD  - Department of Dermatology, Affiliated Hospital of Hainan Medical College, Haikou 
      570102, China.
FAU - Liang, Xiong-An
AU  - Liang XA
AD  - Department of Dermatology, Affiliated Hospital of Hainan Medical College, Haikou 
      570102, China.
FAU - Xie, Zhi-Jie
AU  - Xie ZJ
AD  - Department of Dermatology, Sanya Agricultural Reclamation Hospital, SanYa 57200, 
      China.
FAU - Zheng, Zhi-Ang
AU  - Zheng ZA
AD  - Department of Dermatology, Sanya Agricultural Reclamation Hospital, SanYa 57200, 
      China.
FAU - Pan, Qin-Hui
AU  - Pan QH
AD  - Department of Dermatology, Sanya Agricultural Reclamation Hospital, SanYa 57200, 
      China.
FAU - Xing, Yi-Xiong
AU  - Xing YX
AD  - Department of Dermatology, Sanya Agricultural Reclamation Hospital, SanYa 57200, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Asian Pac J Trop Med
JT  - Asian Pacific journal of tropical medicine
JID - 101533720
RN  - 0 (Chemokine CCL2)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Keratolytic Agents)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - LCH760E9T7 (Acitretin)
RN  - WM0HAQ4WNM (Tacrolimus)
SB  - IM
MH  - Acitretin/therapeutic use
MH  - Adult
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Keratolytic Agents/therapeutic use
MH  - Macrophage Inflammatory Proteins/*blood
MH  - Male
MH  - Middle Aged
MH  - Psoriasis/*blood/*drug therapy/epidemiology
MH  - Tacrolimus/therapeutic use
MH  - Young Adult
OTO - NOTNLM
OT  - Macrophage inflammatory protein-1
OT  - Monocyte chemoattractant protein-1
OT  - Psoriasis vulgaris
EDAT- 2014/07/27 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/07/27 06:00
PHST- 2014/01/10 00:00 [received]
PHST- 2014/03/15 00:00 [revised]
PHST- 2014/06/15 00:00 [accepted]
PHST- 2014/07/27 06:00 [entrez]
PHST- 2014/07/27 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - S1995-7645(14)60098-5 [pii]
AID - 10.1016/S1995-7645(14)60098-5 [doi]
PST - ppublish
SO  - Asian Pac J Trop Med. 2014 Jul;7(7):582-4. doi: 10.1016/S1995-7645(14)60098-5.