PMID- 25063362
OWN - NLM
STAT- MEDLINE
DCOM- 20150521
LR  - 20240321
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1581
DP  - 2014 Sep 18
TI  - Circadian modulation of memory and plasticity gene products in a diurnal species.
PG  - 30-9
LID - S0006-8993(14)00949-4 [pii]
LID - 10.1016/j.brainres.2014.07.020 [doi]
AB  - Cognition is modulated by circadian rhythms, in both nocturnal and diurnal 
      species. Rhythms of clock gene expression occur in brain regions that are outside 
      the master circadian oscillator of the suprachiasmatic nucleus and that control 
      cognitive functions, perhaps by regulating the expression neural-plasticity genes 
      such as brain derived neurotrophic factor (BDNF) and its high affinity receptor, 
      tyrosine kinase B (TrkB). In the diurnal grass rat (Arvicanthis niloticus), the 
      hippocampus shows rhythms of clock genes that are 180 degrees  out of phase with those of 
      nocturnal rodents. Here, we examined the hypothesis that this reversal extends to 
      the optimal phase for learning a hippocampal-dependent task and to the phase of 
      hippocampal rhythms in BDNF/TrkB expression. We used the Morris water maze (MWM) 
      to test for time of day differences in reference memory and monitored daily 
      patterns of hippocampal BDNF/TrkB expression in grass rats. Grass rats showed 
      superior long-term retention of the MWM, when the training and testing occurred 
      during the day as compared to the night, at a time when nocturnal laboratory rats 
      show superior retention; acquisition of the MWM was not affected by time of day. 
      BDNF/TrkB expression was rhythmic in the hippocampus of grass rats, and the phase 
      of the rhythms was reversed compared to that of nocturnal rodents. Our findings 
      provide correlational evidence for the claim that the circadian regulation of 
      cognition may involve rhythms of BDNF/TrkB expression in the hippocampus and that 
      their phase may contribute to species differences in the optimal phase for 
      learning.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Martin-Fairey, Carmel A
AU  - Martin-Fairey CA
AD  - Department of Psychology, Michigan State University, East Lansing, MI 48824, USA. 
      Electronic address: nunez@msu.edu.
FAU - Nunez, Antonio A
AU  - Nunez AA
AD  - Department of Psychology, Michigan State University, East Lansing, MI 48824, USA; 
      Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA. 
      Electronic address: Martinf3@msu.edu.
LA  - eng
GR  - R01 MH053433/MH/NIMH NIH HHS/United States
GR  - R01MH53433/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140722
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Circadian Rhythm/*physiology
MH  - Gene Expression/physiology
MH  - Hippocampus/*physiology
MH  - Male
MH  - Maze Learning/*physiology
MH  - Murinae
MH  - Neuropsychological Tests
MH  - Photoperiod
MH  - Random Allocation
MH  - Receptor, trkB/*metabolism
MH  - Spatial Memory/*physiology
PMC - PMC4157103
MID - NIHMS619793
OTO - NOTNLM
OT  - BDNF/TrkB
OT  - Circadian rhythm
OT  - Cognition
OT  - Hippocampus
OT  - Morris water maze
OT  - Plasticity genes
EDAT- 2014/07/27 06:00
MHDA- 2015/05/23 06:00
PMCR- 2015/09/18
CRDT- 2014/07/27 06:00
PHST- 2014/04/01 00:00 [received]
PHST- 2014/07/11 00:00 [revised]
PHST- 2014/07/14 00:00 [accepted]
PHST- 2014/07/27 06:00 [entrez]
PHST- 2014/07/27 06:00 [pubmed]
PHST- 2015/05/23 06:00 [medline]
PHST- 2015/09/18 00:00 [pmc-release]
AID - S0006-8993(14)00949-4 [pii]
AID - 10.1016/j.brainres.2014.07.020 [doi]
PST - ppublish
SO  - Brain Res. 2014 Sep 18;1581:30-9. doi: 10.1016/j.brainres.2014.07.020. Epub 2014 
      Jul 22.