PMID- 25063538
OWN - NLM
STAT- MEDLINE
DCOM- 20150819
LR  - 20151119
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 24
IP  - 11
DP  - 2014 Nov
TI  - Dietary non-enzymatic antioxidant capacity and the risk of myocardial infarction: 
      a case-control study in Italy.
PG  - 1246-51
LID - S0939-4753(14)00204-X [pii]
LID - 10.1016/j.numecd.2014.06.007 [doi]
AB  - BACKGROUND AND AIMS: Oxidative processes have been related to atherosclerosis, 
      but there is scanty information on the role of dietary antioxidants in the 
      prevention of acute myocardial infarction (AMI). METHODS AND RESULTS: The 
      relationship between non-enzymatic antioxidant capacity (NEAC) and the risk of 
      nonfatal AMI was investigated in a case-control study conducted in Milan, Italy, 
      between 1995 and 2003. Cases were 760 patients below 75 years with a first 
      episode of AMI and controls were 682 patients admitted to hospitals for acute 
      conditions, who completed an interviewer-administered food frequency 
      questionnaire, tested for validity and reproducibility. NEAC (excluding coffee) 
      was measured using Italian food composition tables in terms of ferric 
      reducing-antioxidant power (FRAP), Trolox equivalent antioxidant capacity (TEAC) 
      and total radical-trapping antioxidant parameter (TRAP). The odds ratios (OR) of 
      AMI, and the corresponding 95% confidence intervals (CI), were obtained by 
      multiple logistic regression models including terms for main risk factors of AMI 
      and total energy intake. NEAC was inversely related with the risk of AMI. The ORs 
      for the highest quintile compared with the lowest one were 0.41 (95% CI, 
      0.27-0.63) for FRAP, 0.42 (95% CI, 0.27-0.65) for TEAC and 0.41 (95% CI, 
      0.27-0.62) for TRAP, with significant trends in risk. The inverse relationship 
      was apparently stronger in women and in subjects aged >/= 60 years. CONCLUSIONS: 
      Our results support a favorable role of dietary NEAC in the prevention of AMI, 
      and encourage a high consumption of fruit and vegetables and a moderate 
      consumption of wine and whole cereals.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Rossi, M
AU  - Rossi M
AD  - Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche "Mario 
      Negri", Milan, Italy; Department of Clinical Sciences and Community Health, 
      Universita degli Studi di Milano, Milan, Italy.
FAU - Praud, D
AU  - Praud D
AD  - Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche "Mario 
      Negri", Milan, Italy; Department of Clinical Sciences and Community Health, 
      Universita degli Studi di Milano, Milan, Italy.
FAU - Monzio Compagnoni, M
AU  - Monzio Compagnoni M
AD  - Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche "Mario 
      Negri", Milan, Italy.
FAU - Bellocco, R
AU  - Bellocco R
AD  - Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 
      Milan, Italy; Department of Medical Epidemiology and Biostatistics, Karolinska 
      Institutet, Solna, Sweden.
FAU - Serafini, M
AU  - Serafini M
AD  - Functional Food and Metabolic Stress Prevention Laboratory, Agricolture Research 
      Council, CRA-NUT, Rome, Italy.
FAU - Parpinel, M
AU  - Parpinel M
AD  - Unit of Hygiene and Epidemiology, Department of Biological and Medical Sciences, 
      University of Udine, Udine, Italy.
FAU - La Vecchia, C
AU  - La Vecchia C
AD  - Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche "Mario 
      Negri", Milan, Italy; Department of Clinical Sciences and Community Health, 
      Universita degli Studi di Milano, Milan, Italy. Electronic address: 
      carlo.lavecchia@marionegri.it.
FAU - Tavani, A
AU  - Tavani A
AD  - Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche "Mario 
      Negri", Milan, Italy.
LA  - eng
PT  - Journal Article
DEP - 20140626
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Antioxidants)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antioxidants/*administration & dosage
MH  - Case-Control Studies
MH  - *Diet
MH  - Edible Grain
MH  - Female
MH  - Fruit
MH  - Humans
MH  - Italy/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*epidemiology
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Vegetables
MH  - Wine
MH  - Young Adult
OTO - NOTNLM
OT  - Antioxidants
OT  - Case-control study
OT  - Diet
OT  - Myocardial infarction
OT  - Non-enzymatic antioxidant capacity
OT  - Risk factors
OT  - Total antioxidant capacity
EDAT- 2014/07/27 06:00
MHDA- 2015/08/20 06:00
CRDT- 2014/07/27 06:00
PHST- 2013/11/11 00:00 [received]
PHST- 2014/05/26 00:00 [revised]
PHST- 2014/06/15 00:00 [accepted]
PHST- 2014/07/27 06:00 [entrez]
PHST- 2014/07/27 06:00 [pubmed]
PHST- 2015/08/20 06:00 [medline]
AID - S0939-4753(14)00204-X [pii]
AID - 10.1016/j.numecd.2014.06.007 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2014 Nov;24(11):1246-51. doi: 
      10.1016/j.numecd.2014.06.007. Epub 2014 Jun 26.