PMID- 25064422
OWN - NLM
STAT- MEDLINE
DCOM- 20150421
LR  - 20151214
IS  - 1873-6483 (Electronic)
IS  - 0740-5472 (Linking)
VI  - 47
IP  - 4
DP  - 2014 Oct
TI  - Safety and tolerability of slow-release oral morphine versus methadone in the 
      treatment of opioid dependence.
PG  - 275-81
LID - S0740-5472(14)00094-4 [pii]
LID - 10.1016/j.jsat.2014.05.012 [doi]
AB  - Opioid substitution treatment (OST) for opioid dependence may be limited by 
      adverse events (AEs). Increasing the range of therapeutic options optimizes 
      outcomes and facilitates patient management. An international, multi-center, 
      two-phase study investigated the efficacy and safety of slow-release oral 
      morphine (SROM) versus methadone in patients receiving methadone therapy for 
      opioid dependence. In phase 1 (two way cross-over, 11 weeks each period) patients 
      were randomized to SROM or methadone oral solution. In phase 2 (25 weeks), 
      patients continued treatment with SROM (group A) or switched from methadone to 
      SROM (group B). In total, 211 out of 276 completed phase 1 and 198 entered phase 
      2 (n=95 group A, n=103 group B). Treatment with both SROM and methadone was well 
      tolerated. However, the mean QTc-interval associated with methadone was 
      significantly longer than that under SROM. Higher treatment satisfaction, fewer 
      cravings for heroin, and lower mental stress were reported with SROM. This study 
      adds a significant further weight of evidence that SROM is an effective and well 
      tolerated long-term maintenance treatment for opioid dependence with a beneficial 
      risk profile compared to methadone regarding cardiac effects and supports its 
      clinical utility.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Hammig, Robert
AU  - Hammig R
AD  - Universitare Psychiatrische Dienste Bern, CH-3010 Bern, Switzerland. Electronic 
      address: haemmig@spk.unibe.ch.
FAU - Kohler, Wilfried
AU  - Kohler W
AD  - Burgerhospital, D-60316 Frankfurt am Main, Germany.
FAU - Bonorden-Kleij, Karin
AU  - Bonorden-Kleij K
AD  - Asklepios Klinik Nord Ochsenzoll, D-22765 Hamburg, Germany.
FAU - Weber, Bernd
AU  - Weber B
AD  - Private practice, D-34117 Kassel, Germany.
FAU - Lebentrau, Karin
AU  - Lebentrau K
AD  - Private practice, D-80331 Munich, Germany.
FAU - Berthel, Toni
AU  - Berthel T
AD  - Integrierte Psychiatrie Winterthur, CH-8408 Winterthur, Switzerland.
FAU - Babic-Hohnjec, Lucija
AU  - Babic-Hohnjec L
AD  - Integrierte Psychiatrie Winterthur, CH-8408 Winterthur, Switzerland.
FAU - Vollmert, Christian
AU  - Vollmert C
AD  - Zentralinstitut fur Seelische Gesundheit, D-68159 Mannheim, Germany.
FAU - Hopner, Doris
AU  - Hopner D
AD  - Private practice, D-13357 Berlin, Germany.
FAU - Gholami, Najibulah
AU  - Gholami N
AD  - Psychiatric University Hospital of Zurich, Clinic of Social and General 
      Psychiatry, Research Group on Substance Use Disorders, Switzerland; Arud, Centres 
      for Addiction Medicine, Zurich, Switzerland.
FAU - Verthein, Uwe
AU  - Verthein U
AD  - Zentrum fur Interdisziplinare Suchtforschung, Universitat Hamburg, D-20246 
      Hamburg, Germany.
FAU - Haasen, Christian
AU  - Haasen C
AD  - Zentrum fur Interdisziplinare Suchtforschung, Universitat Hamburg, D-20246 
      Hamburg, Germany.
FAU - Reimer, Jens
AU  - Reimer J
AD  - Zentrum fur Interdisziplinare Suchtforschung, Universitat Hamburg, D-20246 
      Hamburg, Germany.
FAU - Ruckes, Christian
AU  - Ruckes C
AD  - Interdisciplinary Centre for Clinical Trials (IZKS), University Medical Centre of 
      the Johannes Gutenberg University of Mainz, D-55131 Mainz, Germany.
LA  - eng
SI  - ClinicalTrials.gov/NCT01079117
SI  - EudraCT/2008-002185-60
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140610
PL  - United States
TA  - J Subst Abuse Treat
JT  - Journal of substance abuse treatment
JID - 8500909
RN  - 0 (Delayed-Action Preparations)
RN  - 76I7G6D29C (Morphine)
RN  - UC6VBE7V1Z (Methadone)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Cross-Over Studies
MH  - Delayed-Action Preparations
MH  - Europe
MH  - Female
MH  - Humans
MH  - International Cooperation
MH  - Male
MH  - Methadone/administration & dosage/adverse effects/*therapeutic use
MH  - Morphine/administration & dosage/adverse effects/*therapeutic use
MH  - *Opiate Substitution Treatment
MH  - Opioid-Related Disorders/*drug therapy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Opioid dependence
OT  - Opioid substitution treatment
OT  - QTc-interval
OT  - Safety
OT  - Slow-release oral morphine
EDAT- 2014/07/30 06:00
MHDA- 2015/04/22 06:00
CRDT- 2014/07/28 06:00
PHST- 2014/02/16 00:00 [received]
PHST- 2014/05/13 00:00 [revised]
PHST- 2014/05/26 00:00 [accepted]
PHST- 2014/07/28 06:00 [entrez]
PHST- 2014/07/30 06:00 [pubmed]
PHST- 2015/04/22 06:00 [medline]
AID - S0740-5472(14)00094-4 [pii]
AID - 10.1016/j.jsat.2014.05.012 [doi]
PST - ppublish
SO  - J Subst Abuse Treat. 2014 Oct;47(4):275-81. doi: 10.1016/j.jsat.2014.05.012. Epub 
      2014 Jun 10.