PMID- 25064800
OWN - NLM
STAT- MEDLINE
DCOM- 20150512
LR  - 20151119
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 437
DP  - 2014 Nov 1
TI  - Matrix metalloproteinases and left ventricular function and structure in spinal 
      cord injured subjects.
PG  - 136-40
LID - S0009-8981(14)00305-2 [pii]
LID - 10.1016/j.cca.2014.07.018 [doi]
AB  - Subjects with spinal cord injury (SCI) exhibit impaired left ventricular (LV) 
      diastolic function, which has been reported to be attenuated by regular physical 
      activity. This study investigated the relationship between circulating matrix 
      metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) and 
      echocardiographic parameters in SCI subjects and the role of physical activity in 
      this regard. Forty-two men with SCI [19 sedentary (S-SCI) and 23 
      physically-active (PA-SCI)] were evaluated by clinical, anthropometric, 
      laboratory, and echocardiographic analysis. Plasmatic pro-MMP-2, MMP-2, MMP-8, 
      pro-MMP-9, MMP-9, TIMP-1 and TIMP-2 levels were determined by enzyme-linked 
      immunosorbent assay and zymography. PA-SCI subjects presented lower pro-MMP-2 and 
      pro-MMP-2/TIMP-2 levels and improved markers of LV diastolic function (lower E/Em 
      and higher Em and E/A values) than S-SCI ones. Bivariate analysis showed that 
      pro-MMP-2 correlated inversely with Em and directly with E/Em, while MMP-9 
      correlated directly with LV mass index and LV end-diastolic diameter in the whole 
      sample. Following multiple regression analysis, pro-MMP-2, but not physical 
      activity, remained associated with Em, while MMP-9 was associated with LV mass 
      index in the whole sample. These findings suggest differing roles for MMPs in LV 
      structure and function regulation and an interaction among pro-MMP-2, diastolic 
      function and physical activity in SCI subjects.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Schreiber, Roberto
AU  - Schreiber R
AD  - Department of Internal Medicine, University of Campinas, Campinas, Brazil.
FAU - Paim, Layde R
AU  - Paim LR
AD  - Department of Internal Medicine, University of Campinas, Campinas, Brazil.
FAU - de Rossi, Guilherme
AU  - de Rossi G
AD  - Department of Internal Medicine, University of Campinas, Campinas, Brazil.
FAU - Matos-Souza, Jose R
AU  - Matos-Souza JR
AD  - Department of Internal Medicine, University of Campinas, Campinas, Brazil.
FAU - Costa E Silva, Anselmo de A
AU  - Costa E Silva Ade A
AD  - School of Physical Education, University of Campinas, Campinas, SP, Brazil.
FAU - Souza, Cristiane M
AU  - Souza CM
AD  - Department of Internal Medicine, University of Campinas, Campinas, Brazil.
FAU - Borges, Mariane
AU  - Borges M
AD  - School of Physical Education, University of Campinas, Campinas, SP, Brazil.
FAU - Azevedo, Eliza R
AU  - Azevedo ER
AD  - Department of Orthopaedics, School of Medical Sciences, University of Campinas, 
      Campinas, SP, Brazil.
FAU - Alonso, Karina C
AU  - Alonso KC
AD  - Department of Orthopaedics, School of Medical Sciences, University of Campinas, 
      Campinas, SP, Brazil.
FAU - Gorla, Jose I
AU  - Gorla JI
AD  - School of Physical Education, University of Campinas, Campinas, SP, Brazil.
FAU - Cliquet, Alberto Jr
AU  - Cliquet A Jr
AD  - Department of Orthopaedics, School of Medical Sciences, University of Campinas, 
      Campinas, SP, Brazil; Department of Electrical Engineering, University of Sao 
      Paulo (USP), Sao Carlos, SP, Brazil.
FAU - Nadruz, Wilson Jr
AU  - Nadruz W Jr
AD  - Department of Internal Medicine, University of Campinas, Campinas, Brazil. 
      Electronic address: wilnj@fcm.unicamp.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140723
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Biomarkers)
RN  - 0 (TIMP2 protein, human)
RN  - 127497-59-0 (Tissue Inhibitor of Metalloproteinase-2)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
RN  - EC 3.4.24.24 (MMP2 protein, human)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (MMP9 protein, human)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 2/*blood
MH  - Matrix Metalloproteinase 9/*blood
MH  - Matrix Metalloproteinases/blood
MH  - Motor Activity/physiology
MH  - Spinal Cord Injuries/*blood/*diagnosis/enzymology
MH  - Tissue Inhibitor of Metalloproteinase-2/blood
MH  - Ventricular Dysfunction, Left/*blood/*diagnosis/enzymology
MH  - Ventricular Function, Left/physiology
OTO - NOTNLM
OT  - Exercise
OT  - Heart
OT  - Matrix metalloproteinase
OT  - Paraplegia
OT  - Tetraplegia
EDAT- 2014/07/30 06:00
MHDA- 2015/05/13 06:00
CRDT- 2014/07/28 06:00
PHST- 2014/06/05 00:00 [received]
PHST- 2014/07/04 00:00 [revised]
PHST- 2014/07/14 00:00 [accepted]
PHST- 2014/07/28 06:00 [entrez]
PHST- 2014/07/30 06:00 [pubmed]
PHST- 2015/05/13 06:00 [medline]
AID - S0009-8981(14)00305-2 [pii]
AID - 10.1016/j.cca.2014.07.018 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2014 Nov 1;437:136-40. doi: 10.1016/j.cca.2014.07.018. Epub 2014 
      Jul 23.