PMID- 25065076
OWN - NLM
STAT- MEDLINE
DCOM- 20140825
LR  - 20221207
IS  - 1049-510X (Print)
IS  - 1049-510X (Linking)
VI  - 24
IP  - 3
DP  - 2014 Summer
TI  - Maintenance of long-term adequate levels of vitamin d lowers HbA1c in African 
      American patients with type 2 diabetes.
PG  - 335-41
AB  - OBJECTIVES: We examined the long-term effects of enhanced Vitamin D (VitD) 
      supplementation on parameters of type 2 diabetes mellitus (T2DM): serum 
      hemoglobin A1c, low density lipoprotein, high density lipoprotein, and 
      triglyceride for the purpose of determining beneficial VitD levels in T2DM 
      African Americans (AA). DESIGN AND METHODS: Following inclusion criteria, 
      retrospective charts of patients aged > or = 30 years were reviewed. VitD 
      supplementation was given to patients as part of drug regimen over a three year 
      continuum. Pearson correlations were used to assess the relationship between VitD 
      levels and levels of each parameter. Repeated measure analysis of variance was 
      conducted to identify difference in mean levels of each parameter between years 
      with VitD included as part of therapy. RESULTS: Vitamin D supplementation was 
      inversely associated with HbA1c (r = -.286, P = .031). No correlation was found 
      between levels of VitD and levels of LDL, HDL or TG. Hemoglobin A1c levels were 
      found to be significantly different under VitD treatment between year 1 (mean 
      VitD 24.75 microg/mL, mean HbA1c 9.15%, P = .000) and year 2 (mean VitD 33.84 
      microg/mL, mean HbA1c 7.91%, P = .000) and between year 1 and year 3 (mean VitD 
      34.46 microg/mL, mean 7.98% HbA1c P = .000). CONCLUSION: In T2DM AA, significant 
      improvements in HbA1c are obtained with enhanced VitD supplementation as part of 
      drug regimen over time. Our investigation provides the first known evidence of a 
      relationship between enhanced VitD supplementation as part of a pre-existing 
      medical regimen taken over long term and determinants of T2DM in a group of 
      overweight and obese AA with T2DM.
FAU - Green, Rhea T
AU  - Green RT
FAU - Gambhir, Kanwal K
AU  - Gambhir KK
FAU - Nunlee-Bland, Gail
AU  - Nunlee-Bland G
FAU - Odonkor, Wolali A
AU  - Odonkor WA
FAU - Ganta, Vijaya A
AU  - Ganta VA
LA  - eng
GR  - P30 DK079637/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Ethn Dis
JT  - Ethnicity & disease
JID - 9109034
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Triglycerides)
RN  - 0 (Vitamins)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Adult
MH  - *Black or African American
MH  - Diabetes Mellitus, Type 2/*blood/drug therapy/*ethnology
MH  - Dietary Supplements
MH  - Drug Administration Schedule
MH  - Female
MH  - Glycated Hemoglobin/*metabolism
MH  - Humans
MH  - Lipoproteins, LDL/blood
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Time Factors
MH  - Triglycerides/blood
MH  - Vitamin D/blood/*therapeutic use
MH  - Vitamins/*therapeutic use
EDAT- 2014/07/30 06:00
MHDA- 2014/08/26 06:00
CRDT- 2014/07/29 06:00
PHST- 2014/07/29 06:00 [entrez]
PHST- 2014/07/30 06:00 [pubmed]
PHST- 2014/08/26 06:00 [medline]
PST - ppublish
SO  - Ethn Dis. 2014 Summer;24(3):335-41.