PMID- 25065441
OWN - NLM
STAT- MEDLINE
DCOM- 20151214
LR  - 20191210
IS  - 1468-3083 (Electronic)
IS  - 0926-9959 (Linking)
VI  - 29
IP  - 3
DP  - 2015 Mar
TI  - Autoantibodies against TIF-1-gamma and CADM-140 in Spanish patients with clinically 
      amyopathic dermatomyositis (CADM): clinical significance and diagnostic utility.
PG  - 482-9
LID - 10.1111/jdv.12591 [doi]
AB  - BACKGROUND: Patients with clinically amyopathic dermatomyositis (CADM) appear to 
      be at risk for developing cancer and interstitial lung diseases, but population 
      data to confirm this hypothesis are limited. Moreover, CADM presents cutaneous 
      and histological findings that may overlap with subacute cutaneous lupus 
      erythematosus (SCLE). OBJECTIVES: To determine the association between 
      myositis-specific autoantibodies, myositis-associated autoantibodies and CADM in 
      Spanish patients. In addition, to study the usefulness of these autoantibodies in 
      the differential diagnosis between CADM and SCLE. METHODS: Serum samples were 
      tested for myositis-specific autoantibodies and myositis-associated 
      autoantibodies through immunoprecipitation and other standardized methods. 
      RESULTS: Anti-CADM-p140 and anti-p155 antibodies were the only myositis-specific 
      autoantibodies found and were associated with interstitial lung diseases and 
      cancer respectively. No myositis-associated autoantibodies were found in CADM. 
      Moreover, clinical subsets and proportions seemed to differ from Asian cohorts, 
      where anti-CADM-p140 is considered a CADM hallmark antibody and a risk factor for 
      the development of interstitial lung disease. Interestingly, anti-SSA was highly 
      associated with SCLE, whereas no myositis-specific autoantibodies were found in 
      this entity. LIMITATIONS OF THE STUDY: Association between CADM and 
      myositis-specific autoantibodies and differences between CADM and SCLE were 
      tested on a relatively small cohort of patients. CONCLUSION: There is an 
      association between cancer-associated myositis and interstitial lung diseases and 
      their hallmark autoantibodies in our cohort. In addition, the combined 
      determination of myositis-specific autoantibodies and SSA autoantibodies may help 
      to accurately discriminate SCLE from CADM.
CI  - (c) 2014 European Academy of Dermatology and Venereology.
FAU - Cuesta-Mateos, C
AU  - Cuesta-Mateos C
AD  - Departamento de Inmunologia, Instituto de Investigacion Sanitaria Hospital 
      Universitario de la Princesa, Madrid, Spain; IMMED S.L., Immunological and 
      Medicinal Products, Madrid, Spain.
FAU - Colom-Fernandez, B
AU  - Colom-Fernandez B
FAU - Portero-Sainz, I
AU  - Portero-Sainz I
FAU - Tejedor, R
AU  - Tejedor R
FAU - Garcia-Garcia, C
AU  - Garcia-Garcia C
FAU - Concha-Garzon, M J
AU  - Concha-Garzon MJ
FAU - De las Heras-Alonso, M E
AU  - De las Heras-Alonso ME
FAU - Martinez, M A
AU  - Martinez MA
FAU - Juarez, C
AU  - Juarez C
FAU - Munoz-Calleja, C
AU  - Munoz-Calleja C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140728
PL  - England
TA  - J Eur Acad Dermatol Venereol
JT  - Journal of the European Academy of Dermatology and Venereology : JEADV
JID - 9216037
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (Autoantibodies)
RN  - 0 (CADM-140 peptide, human)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Peptides)
RN  - 0 (TIAF1 protein, human)
RN  - Amyopathic dermatomyositis
SB  - IM
MH  - Adult
MH  - Aged
MH  - Apoptosis Regulatory Proteins/*immunology
MH  - Autoantibodies/*immunology
MH  - Dermatomyositis/diagnosis/*immunology
MH  - Female
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins
MH  - Male
MH  - Middle Aged
MH  - Nuclear Proteins/*immunology
MH  - Peptides/*immunology
MH  - Spain
EDAT- 2014/07/30 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/07/29 06:00
PHST- 2013/12/16 00:00 [received]
PHST- 2014/05/13 00:00 [accepted]
PHST- 2014/07/29 06:00 [entrez]
PHST- 2014/07/30 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1111/jdv.12591 [doi]
PST - ppublish
SO  - J Eur Acad Dermatol Venereol. 2015 Mar;29(3):482-9. doi: 10.1111/jdv.12591. Epub 
      2014 Jul 28.