PMID- 25065744
OWN - NLM
STAT- MEDLINE
DCOM- 20141111
LR  - 20181202
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 451
IP  - 4
DP  - 2014 Sep 5
TI  - Baicalin reverse AMPA receptor expression and neuron apoptosis in chronic 
      unpredictable mild stress rats.
PG  - 467-72
LID - S0006-291X(14)01268-6 [pii]
LID - 10.1016/j.bbrc.2014.07.041 [doi]
AB  - Changes of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor 
      expression could impacts the viability of neurons and brain levels of 
      brain-derived neurotrophic factor (BDNF) expression in the key brain structures 
      in the pathophysiology of depressive disorder. In the present study, chronic 
      unpredictable mild stress (CUMS) degraded performance decreased AMPA receptor 
      expression and increased neuron apoptosis. Treatment with baicalin (20, 40mg/kg) 
      significantly reversed these changes. This study demonstrates that baicalin has 
      potent antidepressant effect, likely through up-regulated the expression of AMPA 
      receptor and suppression neuron apoptosis in CUMS-treated rats.
CI  - Copyright (c) 2014. Published by Elsevier Inc.
FAU - Yu, Hai-Yang
AU  - Yu HY
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 210009, PR China.
FAU - Yin, Zhu-Jun
AU  - Yin ZJ
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 210009, PR China.
FAU - Yang, Shui-Jin
AU  - Yang SJ
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 210009, PR China.
FAU - Ma, Shi-Ping
AU  - Ma SP
AD  - Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical 
      University, Nanjing 210009, PR China. Electronic address: spma@cpu.edu.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140724
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Flavonoids)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, AMPA)
RN  - 347Q89U4M5 (baicalin)
RN  - EC 3.4.22.- (Caspase 3)
RN  - P6W5IXV8V9 (glutamate receptor ionotropic, AMPA 2)
SB  - IM
MH  - Anhedonia/drug effects
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Apoptosis/drug effects
MH  - Brain-Derived Neurotrophic Factor/biosynthesis
MH  - Caspase 3/biosynthesis
MH  - Flavonoids/*pharmacology
MH  - Male
MH  - Neurons/pathology
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Receptors, AMPA/*biosynthesis/genetics
MH  - Stress, Psychological/physiopathology
OTO - NOTNLM
OT  - Antidepressant
OT  - Baicalin
OT  - Bax
OT  - Bcl-2
OT  - Caspase-3
OT  - GluR2 subunit
EDAT- 2014/07/30 06:00
MHDA- 2014/11/12 06:00
CRDT- 2014/07/29 06:00
PHST- 2014/07/01 00:00 [received]
PHST- 2014/07/07 00:00 [accepted]
PHST- 2014/07/29 06:00 [entrez]
PHST- 2014/07/30 06:00 [pubmed]
PHST- 2014/11/12 06:00 [medline]
AID - S0006-291X(14)01268-6 [pii]
AID - 10.1016/j.bbrc.2014.07.041 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2014 Sep 5;451(4):467-72. doi: 
      10.1016/j.bbrc.2014.07.041. Epub 2014 Jul 24.