PMID- 25066961
OWN - NLM
STAT- MEDLINE
DCOM- 20151007
LR  - 20211021
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 220
IP  - 1-2
DP  - 2014 Dec 15
TI  - Smell identification in individuals at clinical high risk for schizophrenia.
PG  - 201-4
LID - S0165-1781(14)00597-6 [pii]
LID - 10.1016/j.psychres.2014.07.018 [doi]
AB  - Smell identification deficits exist in schizophrenia, and may be associated with 
      its negative symptoms. Less is known about smell identification and its clinical 
      correlates in individuals at clinical high risk (CHR) for schizophrenia and 
      related psychotic disorders. We examined smell identification, symptoms and IQ in 
      71 clinical high-risk (CHR) subjects and 36 healthy controls. Smell 
      identification was assessed using both the 40-item University of Pennsylvania 
      Smell Identification Test (UPSIT; Doty, R.L., Shaman, P., Kimmelman, C.P., Dann, 
      M.S., 1984. University of Pennsylvania Smell Identification Test: a rapid 
      quantitative olfactory function test for the clinic. Laryngoscope 94, 176-178) 
      and its extracted 12-item Brief Smell Identification Test (Goudsmit, N., Coleman, 
      E., Seckinger, R.A., Wolitzky, R., Stanford, A.D., Corcoran, C., Goetz, R.R., 
      Malaspina, D., 2003. A brief smell identification test discriminates between 
      deficit and non-deficit schizophrenia. Psychiatry Research 120, 155-164). Smell 
      identification did not significantly differ between CHR subjects and controls. 
      Among CHR subjects, smell identification did not predict schizophrenia (N=19; 
      27%) within 2 years, nor was it associated with negative or positive symptoms. 
      This is the third prospective cohort study to examine smell identification in CHR 
      subjects, and overall, findings are inconclusive, similar to what is found for 
      other disorders in adolescents, such as autism spectrum, attention deficit and 
      anxiety disorders. Smell identification deficit may not have clear utility as a 
      marker of emergent schizophrenia and related psychotic disorders.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Gill, Kelly Elizabeth
AU  - Gill KE
AD  - Department of Psychiatry, New York State Psychiatric Institute at Columbia 
      University, 1051 Riverside Drive, New York, NY 10032, USA.
FAU - Evans, Elizabeth
AU  - Evans E
AD  - Department of Psychiatry, New York State Psychiatric Institute at Columbia 
      University, 1051 Riverside Drive, New York, NY 10032, USA.
FAU - Kayser, Jurgen
AU  - Kayser J
AD  - Department of Psychiatry, New York State Psychiatric Institute at Columbia 
      University, 1051 Riverside Drive, New York, NY 10032, USA.
FAU - Ben-David, Shelly
AU  - Ben-David S
AD  - School of Social Work, New York University, New York, NY, USA.
FAU - Messinger, Julie
AU  - Messinger J
AD  - Department of Psychiatry, New York University, New York, NY, USA.
FAU - Bruder, Gerard
AU  - Bruder G
AD  - Department of Psychiatry, New York State Psychiatric Institute at Columbia 
      University, 1051 Riverside Drive, New York, NY 10032, USA.
FAU - Malaspina, Dolores
AU  - Malaspina D
AD  - Department of Psychiatry, New York University, New York, NY, USA.
FAU - Corcoran, Cheryl Mary
AU  - Corcoran CM
AD  - Department of Psychiatry, New York State Psychiatric Institute at Columbia 
      University, 1051 Riverside Drive, New York, NY 10032, USA. Electronic address: 
      cc788@columbia.edu.
LA  - eng
GR  - R21MH086125/MH/NIMH NIH HHS/United States
GR  - K23MH066279/MH/NIMH NIH HHS/United States
GR  - UL1 RR024156/RR/NCRR NIH HHS/United States
GR  - K23 MH066279/MH/NIMH NIH HHS/United States
GR  - P50MH086385/MH/NIMH NIH HHS/United States
GR  - T32 DA007294/DA/NIDA NIH HHS/United States
GR  - UL1RR024156/RR/NCRR NIH HHS/United States
GR  - R21 MH086125/MH/NIMH NIH HHS/United States
GR  - P50 MH086385/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140717
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Olfaction Disorders/*complications/physiopathology
MH  - Olfactory Perception/*physiology
MH  - Prospective Studies
MH  - Psychotic Disorders/*complications/physiopathology
MH  - Schizophrenia/*complications/physiopathology
MH  - Smell/*physiology
MH  - Young Adult
PMC - PMC4252491
MID - NIHMS619805
OTO - NOTNLM
OT  - Negative symptoms
OT  - Odor
OT  - Olfaction
OT  - Prodromal
OT  - Prodrome
OT  - Schizophrenia
OT  - Ultra high risk
EDAT- 2014/07/30 06:00
MHDA- 2015/10/08 06:00
PMCR- 2015/12/15
CRDT- 2014/07/29 06:00
PHST- 2014/02/23 00:00 [received]
PHST- 2014/06/13 00:00 [revised]
PHST- 2014/07/09 00:00 [accepted]
PHST- 2014/07/29 06:00 [entrez]
PHST- 2014/07/30 06:00 [pubmed]
PHST- 2015/10/08 06:00 [medline]
PHST- 2015/12/15 00:00 [pmc-release]
AID - S0165-1781(14)00597-6 [pii]
AID - 10.1016/j.psychres.2014.07.018 [doi]
PST - ppublish
SO  - Psychiatry Res. 2014 Dec 15;220(1-2):201-4. doi: 10.1016/j.psychres.2014.07.018. 
      Epub 2014 Jul 17.