PMID- 25069725
OWN - NLM
STAT- MEDLINE
DCOM- 20160222
LR  - 20150112
IS  - 1559-0283 (Electronic)
IS  - 1085-9195 (Linking)
VI  - 71
IP  - 1
DP  - 2015 Jan
TI  - Association of single nucleotide polymorphisms in tumor necrosis factor-alpha 
      with cervical cancer susceptibility.
PG  - 77-84
LID - 10.1007/s12013-014-0165-4 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) polymorphisms have been reported to play an 
      important role in the development of cervical cancer. But the results remain 
      inconclusive. We performed this study to provide a comprehensive assessment of 
      the association by means of a meta-analysis in which all published studies were 
      included. The studies investigating the associations between cervical cancer risk 
      and TNF-alpha polymorphisms were identified through PubMed, Embase, CNKI, and Chinese 
      BioMedical Literature Database. OR and 95% CI (odds ratio and 95% confidence 
      interval) were calculated using either the fixed or random effects model to 
      assess the associations. We eventually included eighteen case-control studies of 
      SNP -308 G>A and nine studies of SNP -238 G>A. Meta-analysis of the former 
      polymorphism suggested significantly increased risk of cervical cancer associated 
      with the A allele (OR 1.19, 95% CI 1.02-1.38). Subgroup analysis according to 
      ethnicity showed similar results in Caucasians (A vs. G: OR 1.25, 95% CI 
      1.02-1.54; AA vs. GG: OR 1.47, 95% CI 1.04-2.08; AA vs. GA+GG: OR 1.47, 95% CI 
      1.04-2.08). For SNP -238 G>A, a protective association was observed in overall 
      comparisons (A vs. G: OR 0.64, 95% CI 0.51-0.80; AA+GA vs. GG: OR 0.62, 95% CI 
      0.49-0.79) and subgroup analysis of Caucasians (A vs. G: OR 0.67, 95% CI 
      0.53-0.83; AA+GA vs. GG: OR 0.65, 95% CI 0.51-0.82). Our meta-analysis indicates 
      that TNF-alpha polymorphisms may confer susceptibility to cervical cancer in an 
      ethic-specific fashion.
FAU - Jin, Ying
AU  - Jin Y
AD  - Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital 
      Medical University, Beijing, China, jy761228@sina.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Biochem Biophys
JT  - Cell biochemistry and biophysics
JID - 9701934
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - Uterine Cervical Neoplasms/ethnology/*genetics
EDAT- 2014/07/30 06:00
MHDA- 2016/02/24 06:00
CRDT- 2014/07/30 06:00
PHST- 2014/07/30 06:00 [entrez]
PHST- 2014/07/30 06:00 [pubmed]
PHST- 2016/02/24 06:00 [medline]
AID - 10.1007/s12013-014-0165-4 [doi]
PST - ppublish
SO  - Cell Biochem Biophys. 2015 Jan;71(1):77-84. doi: 10.1007/s12013-014-0165-4.