PMID- 25069780
OWN - NLM
STAT- MEDLINE
DCOM- 20150529
LR  - 20181202
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 61
IP  - 10
DP  - 2014 Oct
TI  - Effects of fresh gas flow, tidal volume, and charcoal filters on the washout of 
      sevoflurane from the Datex Ohmeda (GE) Aisys, Aestiva/5, and Excel 210 SE 
      Anesthesia Workstations.
PG  - 935-42
LID - 10.1007/s12630-014-0200-3 [doi]
AB  - PURPOSE: We investigated the effects of tidal volume (VT), fresh gas flow (FGF), 
      and a charcoal filter in the inspiratory limb on the washout of sevoflurane from 
      the following Datex Ohmeda (GE) Anesthesia Workstations (AWSs): Aisys, Aestiva/5, 
      and Excel 210SE. METHODS: After equilibrating the AWSs with 2% sevoflurane, the 
      anesthetic was discontinued, and the absorbent anesthesia breathing circuit 
      (ABC), reservoir bag, and test lung were changed. The lung was ventilated with 
      350 or 200 mL.breath(-1), 15 breaths.min(-1), and a FGF of 10 L.min(-1) while the 
      washout of sevoflurane was performed in triplicate using a calibrated Datex 
      Ohmeda Capnomac Ultima and a calibrated MIRAN SapphIRe XL ambient air analyzer 
      until the concentration was </= 10 parts per million (ppm). The effects of 
      decreasing the FGF to 5 and 2 L.min(-1) after the initial washout and of a 
      charcoal filter in the ABC were recorded separately. RESULTS: The median washout 
      times with the Aisys AWS (14 min, P < 0.01) and the Aestiva/5 (17 min, P < 0.001) 
      with VT 350 mL.breath(-1) were significantly less than that with the Excel 210SE 
      (32 min). The mean (95% confidence interval) washout time with the Aisys 
      increased to 23.5 (21.5 to 25.5) min with VT 200 mL.breath(-1) (P < 0.01). 
      Decreasing the FGF from 10 to 5 and 2 L.min(-1) with the Aisys caused a rebound 
      in sevoflurane concentration to >/= 50 ppm. Placement of a charcoal filter in the 
      inspiratory limb reduced the sevoflurane concentration to < 2 ppm in the Aisys 
      and Aestiva/5 AWSs within two minutes. CONCLUSION: The GE AWSs should be purged 
      with large FGFs and VTs ~350 mL.breath(-1) for ~25 min to achieve 10 ppm 
      sevoflurane. The FGF should be maintained to avoid a rebound in anesthetic 
      concentration. Charcoal filters rapidly decrease the anesthetic concentration to 
      < 2 ppm.
FAU - Sabouri, A Sassan
AU  - Sabouri AS
AD  - Department of Anesthesia, Women and Children's Hospital of Buffalo, SUNY at 
      Buffalo, 219 Bryant ST, Buffalo, NY, 14222, USA.
FAU - Lerman, Jerrold
AU  - Lerman J
FAU - Heard, Christopher
AU  - Heard C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140729
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Methyl Ethers)
RN  - 16291-96-6 (Charcoal)
RN  - 38LVP0K73A (Sevoflurane)
SB  - IM
MH  - Anesthesiology/*instrumentation
MH  - Anesthetics, Inhalation/*analysis
MH  - Charcoal/chemistry
MH  - Equipment Design
MH  - Filtration
MH  - Humans
MH  - Methyl Ethers/*analysis
MH  - Sevoflurane
MH  - Tidal Volume
MH  - Time Factors
EDAT- 2014/07/30 06:00
MHDA- 2015/05/30 06:00
CRDT- 2014/07/30 06:00
PHST- 2014/01/30 00:00 [received]
PHST- 2014/06/18 00:00 [accepted]
PHST- 2014/07/30 06:00 [entrez]
PHST- 2014/07/30 06:00 [pubmed]
PHST- 2015/05/30 06:00 [medline]
AID - 10.1007/s12630-014-0200-3 [doi]
PST - ppublish
SO  - Can J Anaesth. 2014 Oct;61(10):935-42. doi: 10.1007/s12630-014-0200-3. Epub 2014 
      Jul 29.