PMID- 25069847
OWN - NLM
STAT- MEDLINE
DCOM- 20150819
LR  - 20211021
IS  - 1432-1963 (Electronic)
IS  - 0172-8113 (Linking)
VI  - 35
IP  - 6
DP  - 2014 Nov
TI  - [Pleural mesothelioma. Cytology and molecular diagnostics].
PG  - 591-6
LID - 10.1007/s00292-014-1922-2 [doi]
AB  - The definitive diagnosis of malignant mesothelioma (MM) in effusion cytology is 
      often avoided or reluctantly made by cytology alone. The most probable reason for 
      this skepticism is the lack of expertise in cytology among many pathologists and 
      clinicians. When an effusion specimen is composed of cells with unequivocal 
      cytological features of malignancy that have the morphology and immunophenotype 
      of mesothelial cells, the cytological diagnosis of MM is straightforward. 
      However, in the daily routine difficult cases of atypical mesothelial cells are 
      often encountered and additional methods are required to establish an accurate 
      diagnosis. In contrast to reactive mesothelial cells cells of MMs often harbor 
      chromosomal aberrations, most frequently a polysomy in combination with a 9p21 
      deletion. These chromosomal aberrations can easily be detected by multitarget 
      fluorescence in situ hybridization (FISH); therefore, FISH allows a reliable 
      distinction between reactive mesothelial cells and MM cells. In order to be able 
      to discriminate between MM and adenocarcinoma, an immunocytochemical panel 
      consisting of different mesothelial and epithelial markers is very helpful. In 
      most inconclusive cases of atypical mesothelial cells the combination of 
      morphology, immunocytochemistry and FISH allows a better distinction between 
      reactive mesothelial cells and MM in effusion cytology.
FAU - Vlajnic, T
AU  - Vlajnic T
AD  - Institut fur Pathologie, Universitatsspital Basel, Schonbeinstr. 40, 4031, Basel, 
      Schweiz, Tatjana.Vlajnic@usb.ch.
FAU - Savic, S
AU  - Savic S
FAU - Bubendorf, L
AU  - Bubendorf L
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Pleuramesotheliom. Zytologie und molekulare Diagnostik.
PL  - Germany
TA  - Pathologe
JT  - Der Pathologe
JID - 8006541
SB  - IM
MH  - Diagnosis, Differential
MH  - Humans
MH  - Lung/pathology
MH  - Mesothelioma/classification/*genetics/*pathology
MH  - *Molecular Diagnostic Techniques
MH  - Neoplasm Invasiveness
MH  - Pleura/pathology
MH  - Pleural Neoplasms/classification/*genetics/*pathology
MH  - World Health Organization
EDAT- 2014/07/30 06:00
MHDA- 2015/08/20 06:00
CRDT- 2014/07/30 06:00
PHST- 2014/07/30 06:00 [entrez]
PHST- 2014/07/30 06:00 [pubmed]
PHST- 2015/08/20 06:00 [medline]
AID - 10.1007/s00292-014-1922-2 [doi]
PST - ppublish
SO  - Pathologe. 2014 Nov;35(6):591-6. doi: 10.1007/s00292-014-1922-2.