PMID- 25070076
OWN - NLM
STAT- MEDLINE
DCOM- 20150903
LR  - 20141203
IS  - 1873-7714 (Electronic)
IS  - 0163-8343 (Linking)
VI  - 36
IP  - 6
DP  - 2014 Nov-Dec
TI  - Prophylactic use of heparin for deep vein thrombosis in restrained psychiatric 
      patients: a chart review.
PG  - 690-3
LID - S0163-8343(14)00162-5 [pii]
LID - 10.1016/j.genhosppsych.2014.06.007 [doi]
AB  - OBJECTIVE: Physical restraint sometimes causes deep vein thrombosis (DVT) and 
      pulmonary embolism. Although unfractionated heparin (UFH) is used for the 
      prophylaxis of DVT, its effectiveness remained unknown for restrained patients. 
      METHOD: We conducted a chart review of restrained inpatients at Sakuragaoka 
      Memorial Hospital in Japan. Restrained patients received subcutaneous injection 
      of UFH 5000 IU bid from December 2008 to September 2010 [heparin (+) period] 
      while UFH was not used from December 2010 to September 2012 [heparin (-) period]. 
      A Doppler ultrasound scanning was performed to examine the presence of DVT. The 
      incidence of DVT was compared between the two periods by chi-square test. A 
      multiple logistic regression model was used to examine effects of demographic and 
      clinical characteristics on the incidence of DVT. RESULTS: No significant 
      difference was found in the incidence of DVT between the heparin (+) and (-) 
      periods [11.8% (11/93) vs. 11.1% (13/117)]. Sedation [odds ratio (OR) = 3.78], 
      physical comorbidities (OR = 6.29) and a longer duration of restraint (OR = 1.22) 
      were associated with the incidence of DVT. CONCLUSION: The use of UFH was not 
      associated with any reduction in the incidence of DVT in restrained psychiatric 
      patients.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Ishida, Takuto
AU  - Ishida T
AD  - Department of Psychiatry, Sakuragaoka Memorial Hospital, Tokyo, Japan; Department 
      of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan. Electronic 
      address: t_ishi_2750@yahoo.co.jp.
FAU - Suzuki, Takefumi
AU  - Suzuki T
AD  - Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; 
      Department of Psychiatry, Inokashira Hospital, Tokyo, Japan.
FAU - Watanabe, Koichiro
AU  - Watanabe K
AD  - Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; 
      Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, 
      Japan.
FAU - Sakurai, Hitoshi
AU  - Sakurai H
AD  - Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; 
      Department of Psychiatry, Inokashira Hospital, Tokyo, Japan.
FAU - Uchida, Hiroyuki
AU  - Uchida H
AD  - Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; 
      Geriatric Mental Health Program, Centre for Addiction and Mental Health, Toronto, 
      ON, Canada.
FAU - Mimura, Masaru
AU  - Mimura M
AD  - Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20140629
PL  - United States
TA  - Gen Hosp Psychiatry
JT  - General hospital psychiatry
JID - 7905527
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Anticoagulants/administration & dosage/*pharmacology
MH  - Comorbidity
MH  - Conscious Sedation/adverse effects
MH  - Female
MH  - Heparin/administration & dosage/*pharmacology
MH  - Hospitals, Psychiatric
MH  - Humans
MH  - Inpatients
MH  - Male
MH  - Mental Disorders/epidemiology/*therapy
MH  - Middle Aged
MH  - Restraint, Physical/*adverse effects
MH  - Retrospective Studies
MH  - Time Factors
MH  - Treatment Outcome
MH  - Venous Thrombosis/*drug therapy/epidemiology/*etiology
OTO - NOTNLM
OT  - Deep vein thrombosis
OT  - Heparin
OT  - Pulmonary embolism
OT  - Restraint
OT  - Sedation
EDAT- 2014/07/30 06:00
MHDA- 2015/09/04 06:00
CRDT- 2014/07/30 06:00
PHST- 2014/02/17 00:00 [received]
PHST- 2014/06/24 00:00 [revised]
PHST- 2014/06/24 00:00 [accepted]
PHST- 2014/07/30 06:00 [entrez]
PHST- 2014/07/30 06:00 [pubmed]
PHST- 2015/09/04 06:00 [medline]
AID - S0163-8343(14)00162-5 [pii]
AID - 10.1016/j.genhosppsych.2014.06.007 [doi]
PST - ppublish
SO  - Gen Hosp Psychiatry. 2014 Nov-Dec;36(6):690-3. doi: 
      10.1016/j.genhosppsych.2014.06.007. Epub 2014 Jun 29.