PMID- 25070387 OWN - NLM STAT- MEDLINE DCOM- 20150716 LR - 20211021 IS - 1432-1971 (Electronic) IS - 0172-0643 (Print) IS - 0172-0643 (Linking) VI - 36 IP - 1 DP - 2015 Jan TI - Evaluation of post-contrast myocardial t1 in duchenne muscular dystrophy using cardiac magnetic resonance imaging. PG - 49-56 LID - 10.1007/s00246-014-0963-x [doi] AB - The objective of the study was to perform a retrospective pilot study to evaluate the potential of myocardial T1 in assessment of Duchenne muscular dystrophy (DMD) cardiomyopathy. Early identification of DMD cardiac disease, particularly myocardial fibrosis, would allow earlier therapy, potentially improving outcomes. Shortened myocardial T1 measured by cardiac MRI (CMR) is a measure of cardiac fibrosis that may be detected before late gadolinium enhancement (LGE). We hypothesized that the post-contrast T1 obtained from the Look-Locker sequences (T1LL), an easily obtainable surrogate of myocardial T1, would be abnormally shortened in DMD compared with controls. T1LL measurement was performed on 21 DMD subjects and 11 controls; to account for individual variations in gadolinium distribution, myocardial T1LL was divided by blood pool T1LL, deriving T1LL ratios. DMD subjects had shorter mean T1LL ratio than controls (1.42 vs 1.72, p < 0.001). Subset analyses in DMD subjects with normal LVEF and without LGE also demonstrated significantly shorter T1LL ratio (-0.28, p < 0.001 and -0.25, p = 0.028). Post-contrast T1LL ratio is abnormally shortened in DMD compared with controls, even in DMD patients with otherwise normal CMRs. The application of more aggressive therapy for those with shorter T1LL may favorably alter morbidity and improve mortality associated with DMD cardiomyopathy. These data suggest that further prospective evaluation of myocardial T1 will be of benefit to patients with DMD. FAU - Soslow, Jonathan H AU - Soslow JH AD - Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, 2200 Children's Way, Suite 5230 DOT, Nashville, TN, 37232, USA, Jonathan.h.soslow@vanderbilt.edu. FAU - Damon, Bruce M AU - Damon BM FAU - Saville, Benjamin R AU - Saville BR FAU - Lu, Zengqi AU - Lu Z FAU - Burnette, W Bryan AU - Burnette WB FAU - Lawson, Mark A AU - Lawson MA FAU - Parra, David A AU - Parra DA FAU - Sawyer, Douglas B AU - Sawyer DB FAU - Markham, Larry W AU - Markham LW LA - eng GR - UL1 TR000445/TR/NCATS NIH HHS/United States GR - UL1-RR024975-01/RR/NCRR NIH HHS/United States GR - 2 UL1 TR000445-06/TR/NCATS NIH HHS/United States GR - UL1 TR001425/TR/NCATS NIH HHS/United States GR - UL1 RR024975/RR/NCRR NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20140729 PL - United States TA - Pediatr Cardiol JT - Pediatric cardiology JID - 8003849 RN - 0 (Contrast Media) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Adolescent MH - Cardiomyopathies/*diagnosis/*etiology MH - Case-Control Studies MH - Child MH - Contrast Media MH - Female MH - Gadolinium DTPA MH - Humans MH - Magnetic Resonance Imaging/*methods MH - Male MH - Muscular Dystrophy, Duchenne/*complications MH - Pilot Projects MH - Retrospective Studies MH - Young Adult PMC - PMC4439095 MID - NIHMS689638 COIS- Conflict of Interest: The authors have no conflicts of interest. EDAT- 2014/07/30 06:00 MHDA- 2015/07/17 06:00 PMCR- 2016/01/01 CRDT- 2014/07/30 06:00 PHST- 2014/01/23 00:00 [received] PHST- 2014/07/11 00:00 [accepted] PHST- 2014/07/30 06:00 [entrez] PHST- 2014/07/30 06:00 [pubmed] PHST- 2015/07/17 06:00 [medline] PHST- 2016/01/01 00:00 [pmc-release] AID - 10.1007/s00246-014-0963-x [doi] PST - ppublish SO - Pediatr Cardiol. 2015 Jan;36(1):49-56. doi: 10.1007/s00246-014-0963-x. Epub 2014 Jul 29.