PMID- 25070443
OWN - NLM
STAT- MEDLINE
DCOM- 20150518
LR  - 20221207
IS  - 1671-0274 (Print)
IS  - 1671-0274 (Linking)
VI  - 17
IP  - 7
DP  - 2014 Jul
TI  - [Efficacy analysis of laparoscopic sleeve gastrectomy in treatment of obesity 
      with type 2 diabetes mellitus].
PG  - 658-62
AB  - OBJECTIVE: To investigate the efficacy and safety of laparoscopic sleeve 
      gastrectomy(LSG) for the treatment of obesity with type 2 diabetes 
      mellitus(T2DM). METHODS: Clinical data of 32 obesity patients with T2DM patients 
      undergoing LSG from May 2010 to February 2012 in our department were 
      retrospectively analyzed. Their body weight indexes (body weight, waist 
      circumference, BMI, EWL), blood glucose indexes [glycosylated hemoglobin (HbA1c), 
      fasting plasma glucose (FPG), insulin resistance index (HOMA-IR)], and blood 
      lipid indexes [total cholesterol, triglyceride, low density lipoprotein 
      cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C)] were measured 1, 
      3, 6, 12 months after operation and compared with preoperative levels. 
      Improvement in complications was observed. RESULTS: All the patients completed 
      operation under laparoscopy except 1 case because of abdominal cavity adhesion. 
      The average operative time was (115.0+/-19.6) min, and the average blood loss 
      (69.0+/-29.7) ml. No operative death, anastomotic leakage, or surgical site 
      infection were found. The body weight, waist circumference and BMI at 1, 3, 6, 
      and 12 months after surgery were significantly lower(all P<0.05) showing a 
      decreasing trend over time. EWL showed significant increasing trend (P<0.05). 
      During 12 months of follow-up, no over-low weight was observed. From 1 month 
      after surgery, HbA1c, FPG and HOMA-IR decreased significantly (P<0.05). HbA1c and 
      FPG maintained stable level at 12 and 6 months after operation respectively. FPG 
      of 28 patients returned to normal 3 months after operation. Clinical complete 
      remission rate of T2DM was 87.5%(28/32), and clinical partial remission rate was 
      12.5%(4/32) at the 12-month follow-up. Serum total cholesterol, triglyceride and 
      LDL-C decreased obviously after surgery(P<0.05). CONCLUSION: LSG procedure is a 
      safe and effective surgical method in treatment of obesity with T2DM.
FAU - Chang, Xusheng
AU  - Chang X
AD  - Department of Minimally Invasive Surgery, Changhai Hospital, The Second Military 
      Medical University, Shanghai 200433, China. kyin67@126.com.
FAU - Zheng, Chengzhu
AU  - Zheng C
FAU - Wang, Xin
AU  - Wang X
FAU - Zhuo, Guangzuan
AU  - Zhuo G
FAU - Ding, Dan
AU  - Ding D
FAU - Guo, Xiang
AU  - Guo X
FAU - Yin, Kai
AU  - Yin K
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Wei Chang Wai Ke Za Zhi
JT  - Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
JID - 101177990
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
SB  - IM
MH  - Blood Glucose
MH  - Diabetes Mellitus, Type 2/*complications
MH  - *Gastrectomy
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Insulin
MH  - Insulin Resistance
MH  - *Laparoscopy
MH  - Lipids
MH  - Obesity/complications/*surgery
MH  - Remission Induction
MH  - Retrospective Studies
EDAT- 2014/07/30 06:00
MHDA- 2015/05/20 06:00
CRDT- 2014/07/30 06:00
PHST- 2014/07/30 06:00 [entrez]
PHST- 2014/07/30 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
AID - 100001882012 [pii]
PST - ppublish
SO  - Zhonghua Wei Chang Wai Ke Za Zhi. 2014 Jul;17(7):658-62.