PMID- 25071918
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140729
LR  - 20220316
IS  - 1976-8257 (Print)
IS  - 2234-2753 (Electronic)
IS  - 1976-8257 (Linking)
VI  - 30
IP  - 2
DP  - 2014 Jun
TI  - Smoking Habits and Neuropeptides: Adiponectin, Brain-derived Neurotrophic Factor, 
      and Leptin Levels.
PG  - 91-7
LID - 10.5487/TR.2014.30.2.091 [doi]
AB  - This study aimed to identify changes in the level of neuropeptides among current 
      smokers, former smokers, and individuals who had never smoked, and how smoking 
      habits affect obesity and metabolic syndrome (MetS). Neuropeptide levels, 
      anthropometric parameters, and metabolic syndrome diagnostic indices were 
      determined among male workers; 117 of these had never smoked, whereas 58 and 198 
      were former and current smokers, respectively. The total sample comprised 373 
      male workers. The results obtained from anthropometric measurements showed that 
      current smokers attained significantly lower body weight, body mass index, waist 
      circumference, and abdominal fat thickness values than former smokers and those 
      who had never smoked. Current smokers' eating habits proved worse than those of 
      non-smokers and individuals who had never smoked. The level of brain-derived 
      neurotrophic factor (BDNF) in the neuropeptides in the case of former smokers was 
      23.6 +/- 9.2 pg/ml, higher than that of current smokers (20.4 +/- 6.1) and 
      individuals who had never smoked (22.4 +/- 5.8) (F = 6.520, p = 0.002). The level 
      of adiponectin among former smokers was somewhat lower than that of current 
      smokers, whereas leptin levels were higher among former smokers than current 
      smokers; these results were not statistically significant. A relationship was 
      found between adiponectin and triglyceride among non-smokers (odds ratio = 0.660, 
      beta value = -0.416, p < 0.01) and smokers (odds ratio = 0.827, beta value = -0.190, p 
      < 0.05). Further, waist circumference among non-smokers (odds ratio = 1.622, beta 
      value = 0.483, p < 0.001) and smokers (odds ratio = 1.895, beta value = 0.639, p < 
      0.001) was associated with leptin. It was concluded that cigarette smoking leads 
      to an imbalance of energy expenditure and appetite by changing the concentration 
      of neuropeptides such as adiponectin, BDNF, leptin, and hsCRP, and influences 
      food intake, body weight, the body mass index, blood pressure, and abdominal fat, 
      which are risk factors for MetS and cardiovascular disease.
FAU - Kim, Ki-Woong
AU  - Kim KW
AD  - Occupational Safety and Health Research Institute, Korea Occupational Safety and 
      Health Agency, Incheon, Korea.
FAU - Won, Yong Lim
AU  - Won YL
AD  - Occupational Safety and Health Research Institute, Korea Occupational Safety and 
      Health Agency, Incheon, Korea.
FAU - Ko, Kyung Sun
AU  - Ko KS
AD  - Occupational Safety and Health Research Institute, Korea Occupational Safety and 
      Health Agency, Incheon, Korea.
FAU - Roh, Ji Won
AU  - Roh JW
AD  - Occupational Safety and Health Research Institute, Korea Occupational Safety and 
      Health Agency, Incheon, Korea.
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - Toxicol Res
JT  - Toxicological research
JID - 101483324
PMC - PMC4112070
OTO - NOTNLM
OT  - Adiponectine
OT  - BDNF
OT  - Leptin
OT  - Neuropeptides
OT  - Smoking habits
EDAT- 2014/07/30 06:00
MHDA- 2014/07/30 06:01
PMCR- 2014/07/01
CRDT- 2014/07/30 06:00
PHST- 2014/04/14 00:00 [received]
PHST- 2014/06/13 00:00 [revised]
PHST- 2014/06/18 00:00 [accepted]
PHST- 2014/07/30 06:00 [entrez]
PHST- 2014/07/30 06:00 [pubmed]
PHST- 2014/07/30 06:01 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - toxicr-30-91 [pii]
AID - 10.5487/TR.2014.30.2.091 [doi]
PST - ppublish
SO  - Toxicol Res. 2014 Jun;30(2):91-7. doi: 10.5487/TR.2014.30.2.091.