PMID- 25073284
OWN - NLM
STAT- MEDLINE
DCOM- 20150521
LR  - 20181202
IS  - 1002-1892 (Print)
IS  - 1002-1892 (Linking)
VI  - 28
IP  - 5
DP  - 2014 May
TI  - [Correlation analysis of bone marrow edema degree and serum inflammatory factors 
      change with knee joint pain symptoms in patients with bone contusion around the 
      knee joint].
PG  - 615-9
AB  - OBJECTIVE: To explore the correlation between the degree of bone marrow edema 
      (BME) and the content change of tumor necrosis factor alpha (TNF-alpha) and 
      matrix metalloproteinase 3 (MMP-3) and the knee pain symptoms in patients with 
      bone contusion around the knee joint. METHODS: Thirty patients (30 knees) of bone 
      contusion around the knee joint were chosen as the trial group between October 
      2009 and April 2012. According to visual analogue scale (VAS), 30 patients were 
      divided into mild group (10 cases), moderate group (10 cases), and severe group 
      (10 cases); according to MRI morphological changes, the patients were divided 
      into type I group (12 cases), type II group (11 cases), and type III group (7 
      cases). Ten patients (10 knees) with soft tissue injury of the knee were chosen 
      as control group. No significant difference was found (P > 0.05) in gender, age, 
      causes, side, and admission time after injury between 2 groups. The serum 
      contents of MMP-3 and TNF-alpha were detected and statistically analysed between 
      different degrees of pain groups and between different degrees of BME groups. 
      Correlation was analysed between BME and inflammatory factor changes and VAS 
      score. RESULTS: The MMP-3 and TNF-alpha contents in trial group [(29.580 +/- 
      6.870) (microg/L and (23.750 +/- 7.096) ng/L] were significantly higher than 
      those in control group [(8.219 +/- 1.355) microg/L and (6.485 +/- 1.168) ng/L] (t 
      = 9.686, P = 0.000; t = 7.596, P =0.000). The MMP-3 and TNF-alpha contents in 
      patients with different degrees of pain and BME were significantly higher than 
      those in patients of control group (P < 0.05), and significant difference was 
      found between patients with different degrees of pain (P < 0.05), but no 
      significant difference between patients with different degrees of BME (P > 0.05). 
      Multiple linear regression analysis showed that TNF-alpha content was 
      significantly correlated with VAS score (P = 0.000). CONCLUSION: Knee pain 
      symptoms are not related to the degree of BME in patients with bone contusion 
      around the knee joint. Inflammatory factor TNF-alpha content is the main 
      influence factor of knee joint pain symptoms.
FAU - Li, Songiun
AU  - Li S
FAU - An, Rongze
AU  - An R
FAU - Wang, Zhaojie
AU  - Wang Z
FAU - Kuang, Lipeng
AU  - Kuang L
FAU - Tan, Weiyuan
AU  - Tan W
FAU - Fang, Cunxun
AU  - Fang C
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
JT  - Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = 
      Chinese journal of reparative and reconstructive surgery
JID - 9425194
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Arthralgia
MH  - Bone Marrow/metabolism/*pathology
MH  - Cartilage Diseases
MH  - Case-Control Studies
MH  - *Contusions
MH  - Edema/*metabolism
MH  - Humans
MH  - Knee Injuries/metabolism/*pathology
MH  - Knee Joint
MH  - Magnetic Resonance Imaging
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Pain
MH  - Pain Measurement
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 2014/07/31 06:00
MHDA- 2015/05/23 06:00
CRDT- 2014/07/31 06:00
PHST- 2014/07/31 06:00 [entrez]
PHST- 2014/07/31 06:00 [pubmed]
PHST- 2015/05/23 06:00 [medline]
PST - ppublish
SO  - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2014 May;28(5):615-9.