PMID- 25074646
OWN - NLM
STAT- MEDLINE
DCOM- 20150625
LR  - 20141017
IS  - 1661-6758 (Electronic)
IS  - 1661-6499 (Linking)
VI  - 7
IP  - 2
DP  - 2014
TI  - Associations of common variants in methionine metabolism pathway genes with 
      plasma homocysteine and the risk of type 2 diabetes in Han Chinese.
PG  - 63-74
LID - 10.1159/000365007 [doi]
AB  - BACKGROUND/AIMS: An association of genetic variants of homocysteine (Hcy) 
      metabolic genes with type 2 diabetes mellitus (T2DM) has been reported. The 
      objective of the present study was to investigate the relationship between the 
      genetic variants in Hcy metabolism-related genes and plasma Hcy levels and T2DM 
      susceptibility in Han Chinese. METHODS: A total of 774 patients with T2DM and 500 
      healthy individuals were recruited. Single-nucleotide polymorphism was determined 
      by standard methods. RESULTS: The Hcy-increasing allele score was positively 
      associated with plasma Hcy levels in both T2DM patients and healthy subjects (r = 
      0.171 and 0.247, respectively). Subjects with the genotype CC of MTHFR 
      (rs1801131) had a significantly higher likelihood of T2DM compared with subjects 
      with the AA or AA+AC genotypes (OR = 1.93 for CC vs. AA, p = 0.041; OR = 3.13 for 
      CC vs. AA+AC, p = 0.017, respectively). Subjects with the genotype AA of the 
      MTHFD variant (rs2236225) had a significantly lower likelihood of T2DM compared 
      with subjects with the GG or GG+GA genotypes (OR = 0.36 for AA vs. GG, p = 0.027; 
      OR = 0.36 for AA vs. GG+GA, p = 0.017, respectively). In addition, the genotype 
      CT+TT of the PEMT (rs4646356) variants displayed a significant association with 
      an increased risk of T2DM (OR = 1.52 for CT+TT vs. CC, p = 0.042). CONCLUSIONS: 
      MTHFR rs1801131 C allele and PEMT rs4646356 T allele were associated with a high 
      risk of T2DM in these Han Chinese.
CI  - (c) 2014 S. Karger AG, Basel.
FAU - Huang, Tao
AU  - Huang T
AD  - Department of International Health, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, Md., USA.
FAU - Sun, Jianqin
AU  - Sun J
FAU - Chen, Yanqiu
AU  - Chen Y
FAU - Xie, Hua
AU  - Xie H
FAU - Xu, Danfeng
AU  - Xu D
FAU - Li, Duo
AU  - Li D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140725
PL  - Switzerland
TA  - J Nutrigenet Nutrigenomics
JT  - Journal of nutrigenetics and nutrigenomics
JID - 101299758
RN  - 0 (Genetic Markers)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - EC 1.5.1.20 (MTHFR protein, human)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
RN  - EC 2.1.1.17 (PEMT protein, human)
RN  - EC 2.1.1.17 (Phosphatidylethanolamine N-Methyltransferase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - China
MH  - Diabetes Mellitus, Type 2/*blood/*ethnology
MH  - Female
MH  - Genetic Markers
MH  - *Genetic Variation
MH  - Genotype
MH  - Haplotypes
MH  - Homocysteine/*blood/genetics
MH  - Humans
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/genetics
MH  - Middle Aged
MH  - Phosphatidylethanolamine N-Methyltransferase/genetics
MH  - Polymorphism, Single Nucleotide
EDAT- 2014/07/31 06:00
MHDA- 2015/06/26 06:00
CRDT- 2014/07/31 06:00
PHST- 2013/07/15 00:00 [received]
PHST- 2014/05/28 00:00 [accepted]
PHST- 2014/07/31 06:00 [entrez]
PHST- 2014/07/31 06:00 [pubmed]
PHST- 2015/06/26 06:00 [medline]
AID - 000365007 [pii]
AID - 10.1159/000365007 [doi]
PST - ppublish
SO  - J Nutrigenet Nutrigenomics. 2014;7(2):63-74. doi: 10.1159/000365007. Epub 2014 
      Jul 25.