PMID- 25074779
OWN - NLM
STAT- MEDLINE
DCOM- 20141009
LR  - 20220311
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 55
IP  - 8
DP  - 2014 Jul 29
TI  - Improvement of diagnostic performance regarding retinal nerve fiber layer defect 
      using shifting of the normative database according to vessel position.
PG  - 5116-24
LID - 10.1167/iovs.14-14630 [doi]
AB  - PURPOSE: To evaluate the clinical efficacy of early detection of retinal nerve 
      fiber layer (RNFL) defect in a Korean population using shifting of the normative 
      RNFL thickness database according to vessel position. METHODS: Retinal nerve 
      fiber layer thickness data of 151 healthy eyes (normative group) and 120 
      validation subjects (validation group; additional healthy controls plus early 
      glaucoma) were prospectively obtained using spectral-domain optical coherence 
      tomography (SD-OCT) measurement. Clinical profiles and position of major retinal 
      artery peaks (superotemporal, STa; inferotemporal, ITa) were investigated with 
      position of RNFL peaks. Three different criteria for the lower 1% limit were 
      adopted for the validation. Criterion 1 used normative data from the 
      manufacturer. Criterion 2 used data from healthy volunteers. Criterion 3 used 
      four combinations of two subgroups from data for volunteers, which were divided 
      by the median value of STa in the superior region and that of ITa in the inferior 
      region. The kappa value was used to determine the diagnostic performance of each 
      criterion (agreement with standard answer). RESULTS: Assessment of the validation 
      group using criterion 3 showed greater accuracy than with criterion 1 or 
      criterion 2 (kappa = 0.571, 0.774, and 0.979). Although SD-OCT specificity for RNFL 
      defect detection was similar among the criteria (100%, 98.8%, and 98.9%), 
      sensitivity was highest with criterion 3 (42.4%, 72.7%, and 100%) (all values; 
      criteria 1, 2, and 3, respectively). CONCLUSIONS: Shifting of the lower 1% 
      reference line, according to vessel position, could remarkably improve the 
      diagnostic performance regarding RNFL defect detection with SD-OCT.
CI  - Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
FAU - Rho, Seungsoo
AU  - Rho S
AD  - Department of Ophthalmology, CHA Bundang Medical Center, CHA University, 
      Seongnam, Republic of Korea.
FAU - Sung, Youngje
AU  - Sung Y
AD  - Department of Ophthalmology, CHA Bundang Medical Center, CHA University, 
      Seongnam, Republic of Korea.
FAU - Kang, Taebyeong
AU  - Kang T
AD  - Department of Ophthalmology, CHA Bundang Medical Center, CHA University, 
      Seongnam, Republic of Korea.
FAU - Kim, Na Rae
AU  - Kim NR
AD  - Department of Ophthalmology, Inha University School of Medicine, Incheon, 
      Republic of Korea.
FAU - Kim, Chan Yun
AU  - Kim CY
AD  - Institute of Vision Research, Department of Ophthalmology, Yonsei University 
      College of Medicine, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20140729
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Case-Control Studies
MH  - Databases, Factual
MH  - *Diagnostic Techniques, Ophthalmological
MH  - Early Diagnosis
MH  - Female
MH  - Glaucoma/*diagnosis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Sensitivity and Specificity
MH  - Tomography, Optical Coherence/*methods/standards
MH  - Young Adult
OTO - NOTNLM
OT  - glaucoma
OT  - optical coherence tomography
OT  - retinal nerve fiber layer peak
OT  - vessel position
EDAT- 2014/07/31 06:00
MHDA- 2014/10/10 06:00
CRDT- 2014/07/31 06:00
PHST- 2014/07/31 06:00 [entrez]
PHST- 2014/07/31 06:00 [pubmed]
PHST- 2014/10/10 06:00 [medline]
AID - iovs.14-14630 [pii]
AID - 10.1167/iovs.14-14630 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2014 Jul 29;55(8):5116-24. doi: 10.1167/iovs.14-14630.