PMID- 25076170
OWN - NLM
STAT- MEDLINE
DCOM- 20150302
LR  - 20191210
IS  - 1809-452X (Electronic)
IS  - 1516-4446 (Linking)
VI  - 36
IP  - 4
DP  - 2014 Oct-Dec
TI  - Environmental enrichment restores cognitive deficits induced by experimental 
      childhood meningitis.
PG  - 322-9
LID - S1516-44462014005041443 [pii]
LID - 10.1590/1516-4446-2014-1443 [doi]
AB  - OBJECTIVE: To evaluate the influence of environmental enrichment (EE) on memory, 
      cytokines, and brain-derived neurotrophic factor (BDNF) in the brain of adult 
      rats subjected to experimental pneumococcal meningitis during infancy. METHODS: 
      On postnatal day 11, the animals received either artificial cerebrospinal fluid 
      (CSF) or Streptococcus pneumoniae suspension intracisternally at 1 x 10(6) CFU/mL 
      and remained with their mothers until age 21 days. Animals were divided into the 
      following groups: control, control + EE, meningitis, and meningitis + EE. EE 
      began at 21 days and continued until 60 days of age (adulthood). EE consisted of 
      a large cage with three floors, ramps, running wheels, and objects of different 
      shapes and textures. At 60 days, animals were randomized and subjected to 
      habituation to the open-field task and the step-down inhibitory avoidance task. 
      After the tasks, the hippocampus and CSF were isolated for analysis. RESULTS: The 
      meningitis group showed no difference in performance between training and test 
      sessions of the open-field task, suggesting habituation memory impairment; in the 
      meningitis + EE group, performance was significantly different, showing 
      preservation of habituation memory. In the step-down inhibitory avoidance task, 
      there were no differences in behavior between training and test sessions in the 
      meningitis group, showing aversive memory impairment; conversely, differences 
      were observed in the meningitis + EE group, demonstrating aversive memory 
      preservation. In the two meningitis groups, IL-4, IL-10, and BDNF levels were 
      increased in the hippocampus, and BDNF levels in the CSF. CONCLUSIONS: The data 
      presented suggest that EE, a non-invasive therapy, enables recovery from memory 
      deficits caused by neonatal meningitis.
FAU - Barichello, Tatiana
AU  - Barichello T
AD  - Laboratory of Experimental Microbiology, Universidade do Extremo Sul Catarinense 
      (UNESC), Criciuma, SC, Brazil.
FAU - Fagundes, Glauco D
AU  - Fagundes GD
AD  - Laboratory of Experimental Microbiology, Universidade do Extremo Sul Catarinense 
      (UNESC), Criciuma, SC, Brazil.
FAU - Generoso, Jaqueline S
AU  - Generoso JS
AD  - Laboratory of Experimental Microbiology, Universidade do Extremo Sul Catarinense 
      (UNESC), Criciuma, SC, Brazil.
FAU - Dagostin, Caroline S
AU  - Dagostin CS
AD  - Laboratory of Experimental Microbiology, Universidade do Extremo Sul Catarinense 
      (UNESC), Criciuma, SC, Brazil.
FAU - Simoes, Lutiana R
AU  - Simoes LR
AD  - Laboratory of Experimental Microbiology, Universidade do Extremo Sul Catarinense 
      (UNESC), Criciuma, SC, Brazil.
FAU - Vilela, Marcia C
AU  - Vilela MC
AD  - Department of Animal Biology, Universidade Federal de Vicosa (UFV), Vicosa, MG, 
      Brazil.
FAU - Comim, Clarissa M
AU  - Comim CM
AD  - Laboratory of Experimental Neurosciences, Universidade do Sul de Santa Catarina 
      (UNISUL), Palhoca, SC, Brazil.
FAU - Petronilho, Fabricia
AU  - Petronilho F
AD  - Center for Experimental Models in Psychiatry, The University of Texas Medical 
      School at Houston, Houston, TX, USA.
FAU - Quevedo, Joao
AU  - Quevedo J
AD  - Center for Experimental Models in Psychiatry, The University of Texas Medical 
      School at Houston, Houston, TX, USA.
FAU - Teixeira, Antonio L
AU  - Teixeira AL
AD  - Interdisciplinary Laboratory of Medical Investigation, Universidade Federal de 
      Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140725
PL  - Brazil
TA  - Braz J Psychiatry
JT  - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
JID - 100895975
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Brain/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cognition Disorders/*therapy
MH  - Cytokines/*blood
MH  - Disease Models, Animal
MH  - *Environmental Exposure
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Male
MH  - Memory Disorders/*therapy
MH  - Meningitis, Pneumococcal/*therapy
MH  - Neurogenesis/physiology
MH  - Neuronal Plasticity/physiology
MH  - Rats, Wistar
MH  - Recovery of Function
MH  - Reproducibility of Results
MH  - Treatment Outcome
EDAT- 2014/07/31 06:00
MHDA- 2015/03/03 06:00
CRDT- 2014/07/31 06:00
PHST- 2013/11/14 00:00 [received]
PHST- 2014/05/01 00:00 [accepted]
PHST- 2014/07/31 06:00 [entrez]
PHST- 2014/07/31 06:00 [pubmed]
PHST- 2015/03/03 06:00 [medline]
AID - S1516-44462014005041443 [pii]
AID - 10.1590/1516-4446-2014-1443 [doi]
PST - ppublish
SO  - Braz J Psychiatry. 2014 Oct-Dec;36(4):322-9. doi: 10.1590/1516-4446-2014-1443. 
      Epub 2014 Jul 25.