PMID- 25078938
OWN - NLM
STAT- MEDLINE
DCOM- 20140922
LR  - 20220409
IS  - 1488-2310 (Electronic)
IS  - 0008-428X (Print)
IS  - 0008-428X (Linking)
VI  - 57
IP  - 4
DP  - 2014 Aug
TI  - Health-related quality of life following decompression compared to decompression 
      and fusion for degenerative lumbar spondylolisthesis: a Canadian multicentre 
      study.
PG  - E126-33
AB  - BACKGROUND: Decompression alone (D) is a well-accepted treatment for patients 
      with lumbar spinal stenosis (LSS) causing neurogenic claudication; however, D is 
      controversial in patients with LSS who have degenerative spondylolisthesis (DLS). 
      Our goal was to compare the outcome of anatomy-preserving D with decompression 
      and fusion (DF) for patients with grade I DLS. We compared patients with DLS who 
      had elective primary 1-2 level spinal D at 1 centre with a cohort who had 1-2 
      level spinal DF at 5 other centres. METHODS: Patients followed for at least 2 
      years were included. Primary analysis included comparison of change in SF-36 
      physical component summary (PCS) scores and the proportion of patients achieving 
      minimal clinically important difference (MCID) and substantial clinical benefit 
      (SCB). RESULTS: There was no significant difference in baseline SF-36 scores 
      between the groups. The average change in PCS score was 10.4 versus 11.4 (p = 
      0.61) for the D and DF groups, respectively. Sixty-seven percent of the D group 
      and 71% of the DF group attained MCID, while 64% of both D and DF groups attained 
      SCB. There was no significant difference between D and DF for change in PCS score 
      (p = 0.74) or likelihood of reaching MCID (p = 0.81) or SCB (p = 0.85) after 
      adjusting for other variables. CONCLUSION: In select patients with DLS, the 
      outcome of D is comparable to DF at a minimum of 2 years.
FAU - Rampersaud, Y Raja
AU  - Rampersaud YR
AD  - The Division of Orthopaedic Surgery, Department of Surgery, University of 
      Toronto, and the Spinal Program, Krembil Neuroscience Center, Toronto Western 
      Hospital University Health Network, University of Toronto, Toronto, Ont.
FAU - Fisher, Charles
AU  - Fisher C
AD  - The Combined Neurosurgical and Orthopaedic Spine Program (CNOSP), Department of 
      Orthopaedics, University of British Columbia, Vancouver Coastal Health Research 
      Institute, Vancouver General Hospital, Vancouver, BC.
FAU - Yee, Albert
AU  - Yee A
AD  - The Sunnybrook Health Sciences Centre, Toronto, Ont.
FAU - Dvorak, Marcel F
AU  - Dvorak MF
AD  - The Combined Neurosurgical and Orthopaedic Spine Program (CNOSP), Department of 
      Orthopaedics, University of British Columbia, Vancouver Coastal Health Research 
      Institute, Vancouver General Hospital, Vancouver, BC.
FAU - Finkelstein, Joel
AU  - Finkelstein J
AD  - The Sunnybrook Health Sciences Centre, Toronto, Ont.
FAU - Wai, Eugene
AU  - Wai E
AD  - The Division of Orthopaedic Surgery, Department of Surgery, University of Ottawa, 
      The Ottawa Hospital, and the Clinical Epidemiology Program, Ottawa Hospital 
      Research Institute, Ottawa, Ont.
FAU - Abraham, Edward
AU  - Abraham E
AD  - The Atlantic Health Science Corporation, St. John, NB.
FAU - Lewis, Stephen J
AU  - Lewis SJ
AD  - The Division of Orthopaedic Surgery, Department of Surgery, University of 
      Toronto, and the Spinal Program, Krembil Neuroscience Center, Toronto Western 
      Hospital University Health Network, University of Toronto, Toronto, Ont.
FAU - Alexander, David
AU  - Alexander D
AD  - The Dalhousie University, QEII Health Sciences Centre, Halifax, NS.
FAU - Oxner, William
AU  - Oxner W
AD  - The Dalhousie University, QEII Health Sciences Centre, Halifax, NS.
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Multicenter Study
PL  - Canada
TA  - Can J Surg
JT  - Canadian journal of surgery. Journal canadien de chirurgie
JID - 0372715
SB  - IM
MH  - Aged
MH  - Canada
MH  - Combined Modality Therapy
MH  - *Decompression, Surgical
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Linear Models
MH  - Logistic Models
MH  - Lumbar Vertebrae/*surgery
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Retrospective Studies
MH  - *Spinal Fusion
MH  - Spondylolisthesis/*surgery
MH  - Treatment Outcome
PMC - PMC4119126
EDAT- 2014/08/01 06:00
MHDA- 2014/09/23 06:00
PMCR- 2014/08/01
CRDT- 2014/08/01 06:00
PHST- 2014/08/01 06:00 [entrez]
PHST- 2014/08/01 06:00 [pubmed]
PHST- 2014/09/23 06:00 [medline]
PHST- 2014/08/01 00:00 [pmc-release]
AID - 10.1503/cjs.032213 [pii]
AID - 057e126 [pii]
AID - 10.1503/cjs.032213 [doi]
PST - ppublish
SO  - Can J Surg. 2014 Aug;57(4):E126-33. doi: 10.1503/cjs.032213.