PMID- 25080918
OWN - NLM
STAT- MEDLINE
DCOM- 20150908
LR  - 20181202
IS  - 1672-7347 (Print)
IS  - 1672-7347 (Linking)
VI  - 39
IP  - 7
DP  - 2014 Jul
TI  - [Pharmacogenetic research in the association between human leukocyte antigen and 
      adverse drug reactions].
PG  - 749-57
LID - 10.11817/j.issn.1672-7347.2014.07.018 [doi]
AB  - With the rapid development of pharmacogenetics, more and more studies have shown 
      evidence in the association between polymorphisms at the human leukocyte antigen 
      (HLA) loci and severe adverse drug reactions (SADRs). Several HLA-B alleles 
      proved to be associated with SADRs for drugs such as carbamazepine, allopurinol, 
      lamotrigine, and flucloxacillin. The USA Food and Drug Administration (FDA) has 
      even recommended routine screening for HLA-B allele before the use of abacavir 
      and carbamazepine. With the completion of human genome project and the Hapmap 
      project, several new pharmacogenetics approaches such as genome-wide association 
      study (GWAS) have emerged. These newly developed methods will undoubtedly 
      accelerate the identification and clinical utilization of the pharmacogenetic 
      biomakers. In addition, the immunogenetic mechanisms by which the HLA alleles 
      cause SADRs are explored at the cellular and molecular level. This review focuses 
      on the recent progresses in HLA alleles and ADRs regarding both the clinical 
      translation and modern pharmacogenetic methods.
FAU - Xiong, Yan
AU  - Xiong Y
AD  - Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 
      Changsha 410008, China.
FAU - Zhang, Wei
AU  - Zhang W
FAU - Chen, Xiaoping
AU  - Chen X
LA  - chi
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhong Nan Da Xue Xue Bao Yi Xue Ban
JT  - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. 
      Medical sciences
JID - 101230586
RN  - 0 (Dideoxynucleosides)
RN  - 0 (HLA Antigens)
RN  - 33CM23913M (Carbamazepine)
RN  - 63CZ7GJN5I (Allopurinol)
RN  - WR2TIP26VS (abacavir)
SB  - IM
MH  - Allopurinol
MH  - Carbamazepine
MH  - Dideoxynucleosides
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Genome-Wide Association Study
MH  - *HLA Antigens
MH  - Humans
MH  - *Pharmacogenetics
EDAT- 2014/08/02 06:00
MHDA- 2015/09/09 06:00
CRDT- 2014/08/02 06:00
PHST- 2014/08/02 06:00 [entrez]
PHST- 2014/08/02 06:00 [pubmed]
PHST- 2015/09/09 06:00 [medline]
AID - 10.11817/j.issn.1672-7347.2014.07.018 [doi]
PST - ppublish
SO  - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2014 Jul;39(7):749-57. doi: 
      10.11817/j.issn.1672-7347.2014.07.018.