PMID- 25081494
OWN - NLM
STAT- MEDLINE
DCOM- 20150805
LR  - 20141206
IS  - 1878-3252 (Electronic)
IS  - 0946-672X (Linking)
VI  - 29
DP  - 2015 Jan
TI  - Hypoglycemic activity and acute oral toxicity of chromium methionine complexes in 
      mice.
PG  - 136-44
LID - S0946-672X(14)00132-1 [pii]
LID - 10.1016/j.jtemb.2014.07.001 [doi]
AB  - The hypoglycemic activity of chromium methionine (CrMet) in alloxan-induced 
      diabetic (AID) mice was investigated and compared with those of chromium 
      trichloride hexahydrate (CrCl3.6H2O) and chromium nicotinate (CrNic) through a 
      15-day feeding experiment. The acute oral toxicity of CrMet was also investigated 
      in ICR (Institute for Cancer Research) mice by a single oral gavage. The 
      anti-diabetic activity of CrMet was explored in detail from the aspects of body 
      weight (BW), blood glucose, triglyceride, total cholesterol, liver glycogen 
      levels, aspartate transaminase (AST) and alanine transaminase (ALT) levels. The 
      obtained results showed that CrMet had beneficial effects on glucose and lipid 
      metabolism, and might possess hepatoprotective efficacy for diabetes. Daily 
      treatment with 500 and 1000mug Cr/kg BW of CrMet in AID mice for 15 days indicated 
      that this low-molecular-weight organic chromium complex had better 
      bioavailability and more beneficial effects on diabetics than CrCl3.6H2O. CrMet 
      also had advantage over CrNic in the control of AST and ALT activities. Acute 
      toxicity studies revealed that CrMet had low toxicity potential and relatively 
      high safety margins in mice with the LD50 value higher than 10.0g/kg BW. These 
      findings suggest that CrMet might be of potential value in the therapy and 
      protection of diabetes.
CI  - Copyright (c) 2014 Elsevier GmbH. All rights reserved.
FAU - Tang, Hai-yan
AU  - Tang HY
AD  - National Engineering Laboratory for Hydrometallurgical Cleaner Production 
      Technology, Institute of Process Engineering, Beijing 100190, China; Key 
      Laboratory of Green Process and Engineering, Institute of Process Engineering, 
      Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy 
      of Sciences, Beijing 100190, China.
FAU - Xiao, Qing-gui
AU  - Xiao QG
AD  - National Engineering Laboratory for Hydrometallurgical Cleaner Production 
      Technology, Institute of Process Engineering, Beijing 100190, China; Key 
      Laboratory of Green Process and Engineering, Institute of Process Engineering, 
      Chinese Academy of Sciences, Beijing 100190, China. Electronic address: 
      qgxiao@ipe.ac.cn.
FAU - Xu, Hong-bin
AU  - Xu HB
AD  - National Engineering Laboratory for Hydrometallurgical Cleaner Production 
      Technology, Institute of Process Engineering, Beijing 100190, China; Key 
      Laboratory of Green Process and Engineering, Institute of Process Engineering, 
      Chinese Academy of Sciences, Beijing 100190, China.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - National Engineering Laboratory for Hydrometallurgical Cleaner Production 
      Technology, Institute of Process Engineering, Beijing 100190, China; Key 
      Laboratory of Green Process and Engineering, Institute of Process Engineering, 
      Chinese Academy of Sciences, Beijing 100190, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140714
PL  - Germany
TA  - J Trace Elem Med Biol
JT  - Journal of trace elements in medicine and biology : organ of the Society for 
      Minerals and Trace Elements (GMS)
JID - 9508274
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Triglycerides)
RN  - 0R0008Q3JB (Chromium)
RN  - 9005-79-2 (Glycogen)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - AE28F7PNPL (Methionine)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Administration, Oral
MH  - Alanine Transaminase/metabolism
MH  - Animals
MH  - Aspartate Aminotransferases/metabolism
MH  - Blood Glucose/metabolism
MH  - Body Weight/drug effects
MH  - Cholesterol/blood
MH  - Chromium/*administration & dosage/*toxicity
MH  - Diabetes Mellitus, Experimental/blood/pathology
MH  - Glycogen/metabolism
MH  - Hypoglycemic Agents/*pharmacology
MH  - Liver/drug effects/metabolism
MH  - Methionine/*administration & dosage/*toxicity
MH  - Mice, Inbred ICR
MH  - Organ Size/drug effects
MH  - *Toxicity Tests, Acute
MH  - Triglycerides/blood
OTO - NOTNLM
OT  - Acute oral toxicity
OT  - Chromium methionine
OT  - Hypoglycemic activity
OT  - Mice
EDAT- 2014/08/02 06:00
MHDA- 2015/08/06 06:00
CRDT- 2014/08/02 06:00
PHST- 2014/03/06 00:00 [received]
PHST- 2014/06/14 00:00 [revised]
PHST- 2014/07/04 00:00 [accepted]
PHST- 2014/08/02 06:00 [entrez]
PHST- 2014/08/02 06:00 [pubmed]
PHST- 2015/08/06 06:00 [medline]
AID - S0946-672X(14)00132-1 [pii]
AID - 10.1016/j.jtemb.2014.07.001 [doi]
PST - ppublish
SO  - J Trace Elem Med Biol. 2015 Jan;29:136-44. doi: 10.1016/j.jtemb.2014.07.001. Epub 
      2014 Jul 14.