PMID- 25082546
OWN - NLM
STAT- MEDLINE
DCOM- 20150820
LR  - 20141222
IS  - 1743-1328 (Electronic)
IS  - 0161-6412 (Linking)
VI  - 37
IP  - 3
DP  - 2015 Mar
TI  - Evaluation of brain-derived neurotrophic factor in diabetic rats.
PG  - 217-22
LID - 10.1179/1743132814Y.0000000428 [doi]
AB  - OBJECTIVE: Brain-derived neurotrophic factor (BDNF) is a member of neurotrophins 
      family that plays a pivotal role in memory and learning. Brain-derived 
      neurotrophic factor mediates health benefits of physical activity both in humans 
      and animals. The nerve damage and cognitive impairment in diabetic rats are 
      thought to be the result of reduced BDNF levels. The purpose of this study was to 
      examine the effect of short- and long-term moderate forced exercise on BDNF 
      levels in the hippocampus of type 1 diabetic rats. METHODS: A total of 40 male 
      Wistar rats have been divided into four groups [control group, sedentary diabetic 
      (SD) group, diabetic group with 2 week exercise, and diabetic group with 8 week 
      exercise]. Exercised groups were treated with moderate treadmill running for 60 
      minutes per day on a rat treadmill. The animals were tested in a Morris water 
      maze (MWM) for spatial memory and the BDNF levels in the hippocampus were 
      assessed by ELISA kit. RESULTS: The Spatial memory test showed a significant 
      improvement in exercised groups in comparison to sedentary groups. Based on the 
      running protocol no significant difference was found on BDNF levels between 
      groups. DISCUSSION: It was shown that spatial memory was improved by the exercise 
      protocol, while the BDNF levels did not change significantly in any group. As a 
      BDNF secretion in the brain is dependent on running paradigm factor, the protocol 
      chosen might not be intensive or long enough to increase the BDNF levels. 
      Exercise may improve spatial memory in type 1 diabetic rats in a way that BDNF is 
      not included.
FAU - Etemad, Asieh
AU  - Etemad A
FAU - Sheikhzadeh, Farzam
AU  - Sheikhzadeh F
FAU - Asl, Naser Ahmadi
AU  - Asl NA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140801
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition Disorders/physiopathology/therapy
MH  - Diabetes Mellitus, Experimental/*physiopathology/therapy
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hippocampus/*physiopathology
MH  - Male
MH  - Maze Learning/physiology
MH  - Motor Activity/*physiology
MH  - Random Allocation
MH  - Rats, Wistar
MH  - Running/*physiology
MH  - Spatial Memory/physiology
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor,
OT  - Exercise,
OT  - Hippocampus,
OT  - Morris water maze,
OT  - Type 1 diabetes
EDAT- 2014/08/02 06:00
MHDA- 2015/08/21 06:00
CRDT- 2014/08/02 06:00
PHST- 2014/08/02 06:00 [entrez]
PHST- 2014/08/02 06:00 [pubmed]
PHST- 2015/08/21 06:00 [medline]
AID - 10.1179/1743132814Y.0000000428 [doi]
PST - ppublish
SO  - Neurol Res. 2015 Mar;37(3):217-22. doi: 10.1179/1743132814Y.0000000428. Epub 2014 
      Aug 1.