PMID- 25082954
OWN - NLM
STAT- MEDLINE
DCOM- 20160411
LR  - 20150710
IS  - 2047-4881 (Electronic)
IS  - 2047-4873 (Linking)
VI  - 22
IP  - 8
DP  - 2015 Aug
TI  - A randomised trial comparing weight loss with aerobic exercise in overweight 
      individuals with coronary artery disease: The CUT-IT trial.
PG  - 1009-17
LID - 10.1177/2047487314545280 [doi]
AB  - BACKGROUND: We aimed to compare the effect of aerobic interval training (AIT) 
      versus a low energy diet (LED) on physical fitness, body composition, 
      cardiovascular risk factors and symptoms in overweight individuals with coronary 
      artery disease (CAD). METHODS AND DESIGN: Seventy non-diabetic participants with 
      CAD, a BMI>28 kg/m(2) and aged 45 to 75 years were randomised to 12 weeks' AIT at 
      90% peak heart rate three times a week or LED (800-1000 kcal/day) for 8-10 weeks 
      followed by 2-4 weeks' weight maintenance diet. RESULTS: Twenty-six (74%) AIT and 
      29 (83%) LED participants completed intervention per protocol. VO2peak (mL/kg fat 
      free mass(0.67)/min) increased by 10.4% (p = 0.002) following AIT, whereas no 
      change was observed after LED (-3.0%, p = 0.095). The LED group lost 10.6% body 
      weight and 26.6% body fat mass (p < 0.001) compared to 1.6% (p = 0.002) and 5.5% 
      (p < 0.001) following AIT. Waist circumference and visceral abdominal fat were 
      reduced by both interventions but were most pronounced following LED 
      (between-group, p < 0.001). Total cholesterol, non-HDL-C and triglycerides 
      decreased significantly in both groups whereas HDL-C and blood pressure were 
      unchanged. Six participants had their antihypertensive treatment reduced 
      following LED (between-group, p = 0.032). Canadian Cardiovascular Society (CCS), 
      New York Heart Association (NYHA) and anxiety scores were improved, while 
      depressive symptoms remained unchanged. Intention-to-treat analyses including 65 
      participants (93%) were similar to per protocol analysis. CONCLUSION: Both 
      interventions were feasible and effective in achieving the desired effects. LED 
      was superior in improving body composition and blood pressure, whereas effects on 
      lipids and symptoms were similar in the two groups. Thus, both AIT and LED 
      improve the cardiovascular risk profile in overweight individuals with 
      contemporarily treated CAD.
CI  - (c) The European Society of Cardiology 2014.
FAU - Pedersen, Lene R
AU  - Pedersen LR
AD  - Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Denmark 
      lrpedersen@gmail.com.
FAU - Olsen, Rasmus H
AU  - Olsen RH
AD  - Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Denmark.
FAU - Jurs, Anders
AU  - Jurs A
AD  - Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Denmark.
FAU - Astrup, Arne
AU  - Astrup A
AD  - Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
FAU - Chabanova, Elizaveta
AU  - Chabanova E
AD  - Department of Radiology, Herlev Hospital, University of Copenhagen, Denmark.
FAU - Simonsen, Lene
AU  - Simonsen L
AD  - Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, 
      University of Copenhagen, Denmark.
FAU - Wisloff, Ulrik
AU  - Wisloff U
AD  - Department of Circulation and Medical Imaging, K.G. Jebsen Center of Exercise in 
      Medicine, Norwegian University of Science and Technology, Norway.
FAU - Haugaard, Steen B
AU  - Haugaard SB
AD  - Department of Internal Medicine, Amager Hospital and the Clinical Research 
      Center, Hvidovre Hospital, University of Copenhagen, Denmark.
FAU - Prescott, Eva
AU  - Prescott E
AD  - Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Denmark.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140731
PL  - England
TA  - Eur J Prev Cardiol
JT  - European journal of preventive cardiology
JID - 101564430
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Lipids)
SB  - IM
MH  - Adiposity
MH  - Aged
MH  - Antihypertensive Agents/therapeutic use
MH  - Biomarkers/blood
MH  - Blood Pressure/drug effects
MH  - *Caloric Restriction/adverse effects
MH  - Combined Modality Therapy
MH  - Coronary Artery Disease/diagnosis/physiopathology/*therapy
MH  - Denmark
MH  - Exercise Test
MH  - *Exercise Therapy/adverse effects
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Intention to Treat Analysis
MH  - Intra-Abdominal Fat
MH  - Lipids/blood
MH  - Male
MH  - Mental Health
MH  - Middle Aged
MH  - Overweight/diagnosis/physiopathology/*therapy
MH  - Physical Fitness
MH  - Secondary Prevention/*methods
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Treatment Outcome
MH  - Waist Circumference
MH  - *Weight Loss
OTO - NOTNLM
OT  - Exercise
OT  - coronary artery disease
OT  - secondary prevention
OT  - weight loss
EDAT- 2014/08/02 06:00
MHDA- 2016/04/12 06:00
CRDT- 2014/08/02 06:00
PHST- 2014/05/21 00:00 [received]
PHST- 2014/07/08 00:00 [accepted]
PHST- 2014/08/02 06:00 [entrez]
PHST- 2014/08/02 06:00 [pubmed]
PHST- 2016/04/12 06:00 [medline]
AID - 2047487314545280 [pii]
AID - 10.1177/2047487314545280 [doi]
PST - ppublish
SO  - Eur J Prev Cardiol. 2015 Aug;22(8):1009-17. doi: 10.1177/2047487314545280. Epub 
      2014 Jul 31.