PMID- 25083576
OWN - NLM
STAT- MEDLINE
DCOM- 20150514
LR  - 20211021
IS  - 1945-0257 (Electronic)
IS  - 1945-0265 (Print)
IS  - 1945-0257 (Linking)
VI  - 18
IP  - 9
DP  - 2014 Sep
TI  - Tumor necrosis factor-alpha and polycystic ovarian syndrome: a clinical, 
      biochemical, and molecular genetic study.
PG  - 605-9
LID - 10.1089/gtmb.2014.0151 [doi]
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) appears to be linked with 
      hyperandrogenism (HA), increased insulin resistance (IR), and obesity (Ob), which 
      were common features noted with polycystic ovarian syndrome (PCOS). Our aim was 
      to study the role of TNF-alpha in the pathogenesis of IR and Ob in PCOS, as well as a 
      C850T (rs1799724) polymorphism in the promoter region of the TNF-alpha gene, in a 
      group of 204 PCOS patients and 204 age-matched healthy controls. RESULTS: 
      Significant differences were observed between PCOS patients and controls. All the 
      PCOS had elevated body mass index, waist circumference, waist-to-hip ratio, 
      fasting insulin, homeostatic model assessment (HOMA) score, and serum TNF-alpha when 
      compared with controls (p<0.05). Genotype distribution for the C-850T 
      polymorphism was observed with the frequency of the variant T allele being 0% in 
      the PCOS group and 9% in the control group (p=0.0032). CONCLUSIONS: In 
      conclusion, our present results suggest that the TNF-alpha system might contribute to 
      the pathogenesis of HA, Ob, and IR in PCOS independent of a polymorphism of the 
      TNF-alpha C850T (rs1799724) in our population.
FAU - Thathapudi, Sujatha
AU  - Thathapudi S
AD  - 1 Department of Genetics and Molecular Medicine, Vasavi Medical and Research 
      Center , Hyderabad, India .
FAU - Kodati, Vijayalakshmi
AU  - Kodati V
FAU - Erukkambattu, Jayashankar
AU  - Erukkambattu J
FAU - Katragadda, Anuradha
AU  - Katragadda A
FAU - Addepally, Uma
AU  - Addepally U
FAU - Hasan, Qurratulain
AU  - Hasan Q
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140801
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - *Genotype
MH  - Humans
MH  - *Polycystic Ovary Syndrome/blood/genetics/pathology
MH  - *Polymorphism, Genetic
MH  - *Promoter Regions, Genetic
MH  - *Tumor Necrosis Factor-alpha/blood/genetics
PMC - PMC4150372
EDAT- 2014/08/02 06:00
MHDA- 2015/05/15 06:00
PMCR- 2015/09/01
CRDT- 2014/08/02 06:00
PHST- 2014/08/02 06:00 [entrez]
PHST- 2014/08/02 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - 10.1089/gtmb.2014.0151 [pii]
AID - 10.1089/gtmb.2014.0151 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2014 Sep;18(9):605-9. doi: 10.1089/gtmb.2014.0151. 
      Epub 2014 Aug 1.