PMID- 25085642
OWN - NLM
STAT- MEDLINE
DCOM- 20141224
LR  - 20140902
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 83
IP  - 10
DP  - 2014 Sep 2
TI  - Neuronal loss is an early component of subacute sclerosing panencephalitis.
PG  - 938-44
LID - 10.1212/WNL.0000000000000749 [doi]
AB  - OBJECTIVE: We performed diffusion tensor imaging (DTI) and magnetic resonance 
      spectroscopy (MRS) studies in a group of patients with subacute sclerosing 
      panencephalitis (SSPE) in order to estimate the pathologic process underlying the 
      phenotypic variability. METHODS: Patients with SSPE who had MRI including DTI and 
      MRS examinations were evaluated according to their clinical status as determined 
      by the SSPE Scoring System and their mental age as determined by tests 
      appropriate for age and developmental level. Comparisons of fractional anisotropy 
      (FA) and apparent diffusion coefficient (ADC) values and metabolite ratios of 
      frontal periventricular white matter, parieto-occipital periventricular white 
      matter, and globus pallidus in both hemispheres were made between control and 
      SSPE groups, and between SSPE subgroups. RESULTS: Control (n = 18) and SSPE (n = 
      39) groups differed in all DTI and MRS parameters except FA, choline (Cho), and 
      Cho/creatine (Cr). SSPE cases had higher ADC and lower N-acetylaspartate (NAA), 
      NAA/Cho, and NAA/Cr in all regions of interest, suggesting cell loss. Disease 
      progression rate and neurologic deficit appeared to be associated with the degree 
      of ADC elevation and NAA reduction: the group with severe global deterioration 
      had the lowest NAA (230.75 +/- 197.97 in forceps minor), and rapid progression was 
      associated with acute reduction in NAA. CONCLUSIONS: The combination of MRS and 
      diffusion MRI findings suggests neuronal loss can be a primary target in rapidly 
      or subacutely progressing SSPE, and preservation or regeneration of axonal 
      structure may be beneficial in chronic cases.
CI  - (c) 2014 American Academy of Neurology.
FAU - Yuksel, Deniz
AU  - Yuksel D
AD  - From the Department of Pediatric Neurology (D.Y.), Dr. Sami Ulus Children's 
      Hospital, Ankara; Department of Radiology (B.D., H.U.), Ankara Medicana Hospital, 
      Ankara; Department of Pediatric Neurology (S.A.), Cukurova University Faculty of 
      Medicine, Adana; and Department of Pediatric Neurology (B.A.), Hacettepe 
      University Faculty of Medicine, Ankara, Turkey. drdeniz_yuksel@yahoo.com.tr.
FAU - Diren, Baris
AU  - Diren B
AD  - From the Department of Pediatric Neurology (D.Y.), Dr. Sami Ulus Children's 
      Hospital, Ankara; Department of Radiology (B.D., H.U.), Ankara Medicana Hospital, 
      Ankara; Department of Pediatric Neurology (S.A.), Cukurova University Faculty of 
      Medicine, Adana; and Department of Pediatric Neurology (B.A.), Hacettepe 
      University Faculty of Medicine, Ankara, Turkey.
FAU - Ulubay, Hakan
AU  - Ulubay H
AD  - From the Department of Pediatric Neurology (D.Y.), Dr. Sami Ulus Children's 
      Hospital, Ankara; Department of Radiology (B.D., H.U.), Ankara Medicana Hospital, 
      Ankara; Department of Pediatric Neurology (S.A.), Cukurova University Faculty of 
      Medicine, Adana; and Department of Pediatric Neurology (B.A.), Hacettepe 
      University Faculty of Medicine, Ankara, Turkey.
FAU - Altunbasak, Sakir
AU  - Altunbasak S
AD  - From the Department of Pediatric Neurology (D.Y.), Dr. Sami Ulus Children's 
      Hospital, Ankara; Department of Radiology (B.D., H.U.), Ankara Medicana Hospital, 
      Ankara; Department of Pediatric Neurology (S.A.), Cukurova University Faculty of 
      Medicine, Adana; and Department of Pediatric Neurology (B.A.), Hacettepe 
      University Faculty of Medicine, Ankara, Turkey.
FAU - Anlar, Banu
AU  - Anlar B
AD  - From the Department of Pediatric Neurology (D.Y.), Dr. Sami Ulus Children's 
      Hospital, Ankara; Department of Radiology (B.D., H.U.), Ankara Medicana Hospital, 
      Ankara; Department of Pediatric Neurology (S.A.), Cukurova University Faculty of 
      Medicine, Adana; and Department of Pediatric Neurology (B.A.), Hacettepe 
      University Faculty of Medicine, Ankara, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20140801
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/metabolism/*pathology
MH  - Child
MH  - Diffusion Tensor Imaging
MH  - Disease Progression
MH  - Female
MH  - Globus Pallidus/metabolism/pathology
MH  - Humans
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Phenotype
MH  - Subacute Sclerosing Panencephalitis/classification/metabolism/*pathology
MH  - White Matter/metabolism/pathology
MH  - Young Adult
EDAT- 2014/08/03 06:00
MHDA- 2014/12/30 06:00
CRDT- 2014/08/03 06:00
PHST- 2014/08/03 06:00 [entrez]
PHST- 2014/08/03 06:00 [pubmed]
PHST- 2014/12/30 06:00 [medline]
AID - WNL.0000000000000749 [pii]
AID - 10.1212/WNL.0000000000000749 [doi]
PST - ppublish
SO  - Neurology. 2014 Sep 2;83(10):938-44. doi: 10.1212/WNL.0000000000000749. Epub 2014 
      Aug 1.