PMID- 25086702
OWN - NLM
STAT- MEDLINE
DCOM- 20150706
LR  - 20211021
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 30 Suppl 2
DP  - 2014 Dec
TI  - Late gadolinium enhancement magnetic resonance imaging for the assessment of 
      myocardial infarction: comparison of image quality between single and double 
      doses of contrast agents.
PG  - 129-35
LID - 10.1007/s10554-014-0505-x [doi]
AB  - To compare the image quality of late gadolinium enhancement (LGE) cardiac 
      magnetic resonance imaging (CMR) using a single dose of gadolinium contrast agent 
      versus the conventional double dose for assessing myocardial infarction. This 
      retrospective study examined 37 patients with chronic myocardial infarction who 
      underwent LGE CMR using both inversion recovery (IR)-turbo fast low-angle shot 
      magnitude-reconstructed and phase-sensitive images with two different dosages of 
      gadolinium contrast agent: a single dose of 0.1 mmol/kg gadolinium-DTPA in 17 
      patients and a double dose of 0.2 mmol/kg in 20 patients. The contrast-to-noise 
      ratio (CNR) and visual conspicuity between infarct and normal myocardium 
      (CNRinfarct-normal, conspicuityinfarct-normal) and between infarct and left 
      ventricular cavity (CNRinfarct-LVC, conspicuityinfarct-LVC) were compared. 
      Interobserver agreement for the maximal transmural extent of infarction was also 
      evaluated. CNRinfarct-normal was significantly higher with double-dose gadolinium 
      contrast agent (15.5 +/- 20.7 vs. 40.4 +/- 16.1 in magnitude images and 9.5 +/- 2.8 vs. 
      11.2 +/- 2.7 in phase-sensitive images, P < 0.001) while conspicuityinfarct-normal 
      showed no significant difference between the two groups (P > 0.05). Both 
      CNRinfarct-LVC (7.7 +/- 10.7 vs. -6.6 +/- 19.0 in magnitude images and 4.1 +/- 2.3 vs. 
      -0.4 +/- 4.1 in phase-sensitive images, P < 0.05) and conspicuityinfarct-LVC were 
      significantly better with single-dose gadolinium contrast. Interobserver 
      agreement for assessing the transmural extent of infarction was moderate in both 
      groups: 0.591 for single-dose and 0.472 for double-dose. LGE CMR using a single 
      dose of gadolinium contrast agent showed significantly better contrast between 
      infarcted myocardium and left ventricular cavity lumen without a significant 
      decrease in visual contrast between infarcted myocardium and normal myocardium, 
      compared to a double dose.
FAU - Kim, Yeo Koon
AU  - Kim YK
AD  - Department of Radiology, Institute of Radiation Medicine, Seoul National 
      University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.
FAU - Park, Eun-Ah
AU  - Park EA
FAU - Lee, Whal
AU  - Lee W
FAU - Kim, Sang Yoon
AU  - Kim SY
FAU - Chung, Jin Wook
AU  - Chung JW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140803
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Contrast Media/*administration & dosage
MH  - Female
MH  - Gadolinium DTPA/*administration & dosage
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*pathology
MH  - Myocardium/*pathology
MH  - Observer Variation
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Signal-To-Noise Ratio
EDAT- 2014/08/05 06:00
MHDA- 2015/07/07 06:00
CRDT- 2014/08/04 06:00
PHST- 2014/06/09 00:00 [received]
PHST- 2014/07/18 00:00 [accepted]
PHST- 2014/08/04 06:00 [entrez]
PHST- 2014/08/05 06:00 [pubmed]
PHST- 2015/07/07 06:00 [medline]
AID - 10.1007/s10554-014-0505-x [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2014 Dec;30 Suppl 2:129-35. doi: 
      10.1007/s10554-014-0505-x. Epub 2014 Aug 3.